Actively Recruiting
High-intensity Inspiratory Muscle Training in Patients With Asthma
Led by Istanbul Medipol University Hospital · Updated on 2024-08-09
34
Participants Needed
1
Research Sites
53 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to examine the effects of high-intensity and low-intensity inspiratory muscle training added to the standard pulmonary rehabilitation exercise program including aerobic and peripheral muscle strengthening training on respiratory muscle function, exercise capacity, dyspnea and health-related quality of life in asthmatic patients. The aim of the study was to examine whether there are intra-group changes and inter-group differences in the groups where low and high intensity inspiratory muscle training was applied. The cases meeting the inclusion criteria will be randomized and divided into two groups, the groups will be named as High Intensity Inspiratory Muscle Training Group (H-IMT) and Low Intensity Inspiratory Muscle Training Group (L-IMT).
CONDITIONS
Official Title
High-intensity Inspiratory Muscle Training in Patients With Asthma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 18 and 65 years old
- Diagnosed with severe persistent, non-allergic asthma by a pulmonologist according to GINA guidelines
- Presence of type 2 inflammation markers such as peripheral eosinophils <150/µL and/or negative skin prick test and/or total IgE <30 kU/L
- Bronchodilator response defined as >12% or 200 mL improvement in FEV1% predicted after 400 mg salbutamol
- Diagnosis made at least 6 months ago and asthma is under control or follow-up
You will not qualify if you...
- Respiratory tract infection within the last month
- Smoking history of more than 10 pack-years or smoking within 6 months after quitting
- Oral corticosteroid treatment within the last 4 weeks
- Body Mass Index greater than 35
- Diagnosis of Eosinophilic Granulomatosis Polyangiitis or Allergic Bronchopulmonary Aspergillosis
- Presence of vasculitis
- History of malignancy
- Pregnancy
- Previous lung surgery or long-term oxygen therapy use
- Presence of restrictive lung diseases or neuromuscular diseases that impair respiratory testing and rehabilitation
- Cognitive dysfunction, mental retardation, or dementia preventing protocol adherence or result interpretation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Esra Pehli̇van
Istanbul, Üsküdar, Turkey (Türkiye), 34668
Actively Recruiting
Research Team
C
Cahidenur Koçak
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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