Actively Recruiting
High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
Led by VA Office of Research and Development · Updated on 2025-12-12
200
Participants Needed
2
Research Sites
191 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems. Frailty leads to poorer physical performance and functional capacity and higher risk of adverse outcomes including falls, hospitalization, and mortality. Resilience, defined as the capacity to recover from disruptions to homeostasis, is critical to successful aging because it precedes frailty and enhances adults' ability to maintain optimal health and function well into older age. Evidence- based therapies to help older adults enhance resilience are limited and the biological underpinnings contributing to improved resilience have not yet been fully characterized. To address this important need, the investigators will conduct a clinical trial to examine the benefits of center- and home-based high intensity interval training (HIIT) on functional capacity, frailty, and resilience, and also to identify novel biomarkers of resilience in older Veterans.
CONDITIONS
Official Title
High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 65 years and older
- Male and female, any race
- Medically cleared for exercise
- Non-frail or pre-frail (frailty score < 3)
- Ability to use a recumbent exercise bike
You will not qualify if you...
- Severe co-morbidity such as COPD (GOLD stage IV), chronic kidney disease (stage 3), or severe hypertension (180 mmHg/120 mmHg)
- Cognitive impairment with a VA-SLUMS score of 20 or lower
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Kansas City VA Medical Center, Kansas City, MO
Kansas City, Missouri, United States, 64128-2226
Actively Recruiting
2
Kansas City VA Medical Center, Kansas City, MO
Kansas City, Missouri, United States, 64128
Not Yet Recruiting
Research Team
K
Kenneth L Seldeen, PhD
CONTACT
B
Bruce R Troen, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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