Actively Recruiting
High-Intensity, Low-Frequency Periodic rTMS Over the Right Dorsolateral Prefrontal Cortex on Cardiac Autonomic Regulation in Women With Recurrent Pregnancy Loss and Anxiety
Led by Shenyang Jinghua Hospital · Updated on 2026-04-21
55
Participants Needed
3
Research Sites
49 weeks
Total Duration
On this page
Sponsors
S
Shenyang Jinghua Hospital
Lead Sponsor
C
Central Hospital Affiliated to Shenyang Medical Collage
Collaborating Sponsor
AI-Summary
What this Trial Is About
This proof-of-concept trial investigates whether high-intensity, low-frequency repetitive transcranial magnetic stimulation (rTMS) targeting the right dorsolateral prefrontal cortex (DLPFC) can improve autonomic cardiac regulation in women with recurrent pregnancy loss (RPL) and anxiety. The study explores the lateralised function of the DLPFC in emotional and autonomic control and tests a novel neuromodulation-based strategy to relieve anxiety and sympathetic overactivation.
CONDITIONS
Official Title
High-Intensity, Low-Frequency Periodic rTMS Over the Right Dorsolateral Prefrontal Cortex on Cardiac Autonomic Regulation in Women With Recurrent Pregnancy Loss and Anxiety
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female, aged 18 to 45 years, and right-handed
- Diagnosis of recurrent pregnancy loss with two or more consecutive miscarriages before 28 weeks of gestation
- Currently not pregnant or presenting with a missed abortion confirmed by ultrasound
- Hamilton Anxiety Rating Scale score of 14 or higher and Hamilton Depression Rating Scale score below 17
- Confirmed diagnosis of at least one DSM-5 anxiety disorder subtype including generalized anxiety disorder, panic disorder, social anxiety disorder, or post-traumatic stress disorder based on a psychiatric interview
You will not qualify if you...
- Contraindications to transcranial magnetic stimulation such as metallic implants or history of epilepsy
- Uncontrolled blood pressure with systolic above 180 mmHg or below 90 mmHg
- Presence of major medical conditions including hyperthyroidism, atrial fibrillation, valvular heart disease, sinus bradycardia, neurological or cerebrovascular disorders, or chronic pulmonary disease
- Clinically significant suicide risk
- Current or past diagnosis of other psychiatric disorders including substance use disorders, schizophrenia, delusional disorder, psychotic disorders, bipolar disorder, or delirium
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
The Second Affiliated Hospital of Shenyang Medical College
Shenyang, Liaoning, China, 110001
Actively Recruiting
2
Shenyang Jinghua Hospital
Shenyang, Liaoning, China, China
Actively Recruiting
3
Central Hospital Affiliated to Shenyang Medical Collage
Shenyang, Liaoning, China
Actively Recruiting
Research Team
Y
Yun-En Liu, MD
CONTACT
L
Lin Tao, MM
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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