Actively Recruiting
High-Intensity, Low-Frequency Periodic rTMS Over the Right Dorsolateral Prefrontal Cortex on Cardiac Autonomic Regulation in Women With Recurrent Pregnancy Loss and Anxiety
Led by Shenyang Medical College · Updated on 2026-04-24
46
Participants Needed
2
Research Sites
23 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine whether high-intensity, low-frequency periodic repetitive transcranial magnetic stimulation (rTMS) applied to the right dorsolateral prefrontal cortex (DLPFC) can modulate cardiac autonomic regulation in women with recurrent pregnancy loss (RPL) and comorbid anxiety. The main questions it aims to answer are: Does 120% resting motor threshold (RMT) rhythmic low-frequency rTMS reduce heart rate during stimulation time windows compared with sham stimulation? Does 120% RMT rTMS alter heart-rate-variability (HRV) spectral power at the target frequency (0.0167 Hz) compared with sham stimulation? Researchers will compare active rTMS with sham rTMS to determine whether the active intervention produces measurable changes in cardiac autonomic activity. Participants will: Undergo a single session of rTMS or sham stimulation consisting of 20 consecutive stimulation time windows (each 60 seconds: 40 seconds of 1-Hz stimulation plus 20 seconds of rest) targeting the right DLPFC; Have continuous electrocardiography (ECG) recordings collected during the entire stimulation session; Complete clinical and psychiatric assessments before participation.
CONDITIONS
Official Title
High-Intensity, Low-Frequency Periodic rTMS Over the Right Dorsolateral Prefrontal Cortex on Cardiac Autonomic Regulation in Women With Recurrent Pregnancy Loss and Anxiety
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female, aged 18-45 years, and right-handed
- Diagnosed with recurrent pregnancy loss (two or more consecutive miscarriages before 28 weeks gestation)
- Not currently pregnant or in a missed miscarriage state
- Diagnosed with an anxiety disorder according to DSM-5 criteria
You will not qualify if you...
- Contraindications to transcranial magnetic stimulation, such as metallic implants or epilepsy history
- Unstable blood pressure (systolic >180 mmHg or <90 mmHg)
- Major organic disorders including hyperthyroidism, atrial fibrillation, valvular heart disease, sinus bradycardia, neurological, cerebrovascular, or pulmonary diseases
- Significant risk of suicide
- Other psychiatric disorders including substance use, schizophrenia, delusional disorder, psychotic disorders, bipolar disorder, or delirium
AI-Screening
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Trial Site Locations
Total: 2 locations
1
The Second Affiliated Hospital of Shenyang Medical College
Shenyang, Liaoning, China, 110001
Actively Recruiting
2
Central Hospital Affiliated to Shenyang Medical College
Shenyang, Liaoning, China, 110024
Actively Recruiting
Research Team
F
Fei Meng, MD
CONTACT
L
Lin Tao, MM
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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