Comparing High-Intensity Strength Training and Endurance Training for People Recovering from COPD Exacerbation A Study on Muscle Strength, Breathlessness, and Exercise Tolerance After Hospital Discharge

What this Trial Is About

Researchers are evaluating two types of early rehabilitation for people recovering from a COPD exacerbation, focusing on severe leg muscle weakness, especially in the quadriceps. The study compares a maximal strength training MST program using high loads and few repetitions to a traditional high-intensity endurance training program. The goal is to see which approach is easier to tolerate, especially regarding breathlessness, and which best improves muscle strength, efficiency, and overall exercise tolerance during recovery. Participants are randomly assigned to one of two training groups. The experimental group performs high-intensity resistance training HIRT with 4 sets of 5 repetitions at 90-95% of their maximum leg press strength, combined with low-intensity cycling at 20% of maximum workload. Sessions occur 5 times per week with a 2 days on, 1 day off cycle. The control group performs high-intensity endurance training HIET cycling at 70% of maximum workload for 25 minutes with progression based on symptoms, combined with low-intensity leg press strength training without progression. After 15 sessions, participants are evaluated and continue a combined training program until discharge. During the study, participants undergo assessments including walking tests, muscle strength measurements, ultrasound scans of muscles and diaphragm, quality of life questionnaires, and fatigue scales at enrollment, after 15 sessions, and at discharge. Researchers monitor heart rate, oxygen levels, symptoms, and side effects such as muscle soreness. The main outcome is reduction in breathlessness during daily activities. Secondary outcomes include functional capacity, fatigue, muscle strength, disease impact, walking efficiency, and satisfaction with training. The trial lasts up to about three weeks post-randomization, providing detailed monitoring throughout rehabilitation.

High-intensity Resistance Training in Post-exacerbation COPD