Actively Recruiting
High-intensity Resistance Training in Post-exacerbation COPD
Led by Istituti Clinici Scientifici Maugeri SpA · Updated on 2025-12-24
64
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
Sponsors
I
Istituti Clinici Scientifici Maugeri SpA
Lead Sponsor
U
Universita di Verona
Collaborating Sponsor
AI-Summary
What this Trial Is About
After a COPD exacerbation, many individuals experience severe weakness in the leg muscles, especially the quadriceps. This weakness can make daily activities difficult and slow down recovery. Traditional respiratory rehabilitation usually focuses on endurance training, which is effective but often hard to tolerate soon after an exacerbation due to persistent symptoms and limited functional capacity. This study aims to compare two early rehabilitation approaches during recovery from a COPD exacerbation: a maximal strength training (MST) programme using high loads and few repetitions, and a traditional endurance-based training programme. The investigators aim to determine whether MST is easier to tolerate, especially in terms of breathlessness, and whether MST can improve muscle strength, efficiency, and overall exercise tolerance as well as or better than endurance training. The results will help identify the most suitable rehabilitation strategy for individuals recovering from a COPD exacerbation, particularly for those who struggle with high-intensity endurance exercise.
CONDITIONS
Official Title
High-intensity Resistance Training in Post-exacerbation COPD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of COPD according to GOLD guidelines with FEV1/FVC <70%
- Clinically stable with pH >7.30
- Discharged from hospital within 3 weeks after acute COPD exacerbation
- Able to perform the six-minute walk test without major motor disability
You will not qualify if you...
- Lung diseases other than COPD
- Orthopedic or neurological conditions preventing functional tests
- Severe neurological, cardiologic, or other diseases limiting exercise tolerance
- Cognitive impairment with MMSE score less than 25
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
ICS Maugeri IRCCS, Respiratory rehabilitation of the Institute of Lumezzane
Lumezzane, Brescia, Italy, 25065
Actively Recruiting
Research Team
M
Mara Paneroni, PhD, MSc
CONTACT
T
Tiziana Bachetti, Pharm
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here