Actively Recruiting
High PEEP in Noninvasive Ventilation Patients With Pneumonia or ARDS
Led by Chongqing Medical University · Updated on 2026-01-07
706
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Noninvasive ventilation is commonly employed in patients with pneumonia or acute respiratory distress syndrome (ARDS) and has been shown to reduce the need for intubation and invasive mechanical ventilation. However, the rate of noninvasive ventilation failure remains substantial, at approximately 40%. Compared with patients in whom noninvasive ventilation succeeds, those who experience noninvasive ventilation failure have a higher likelihood of mortality during their intensive care unit or hospital stay. Therefore, improving the success rate of noninvasive ventilation is clinically important. In patients with lung consolidation receiving invasive mechanical ventilation, high positive end-expiratory pressure (PEEP) can improve oxygenation. Noninvasive ventilation operates on similar physiological principles and can also deliver high PEEP via a mask interface. Nevertheless, there is limited evidence regarding the use of high PEEP during mask-delivered noninvasive ventilation. This study aimed to evaluate whether high PEEP can increase intubation-free survival in patients with pneumonia or ARDS who are treated with noninvasive ventilation.
CONDITIONS
Official Title
High PEEP in Noninvasive Ventilation Patients With Pneumonia or ARDS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than 18 years
- PaO2/FiO2 ratio less than or equal to 300 mmHg or SpO2/FiO2 ratio less than or equal to 315 (with SpO2 at least 97%)
- Expected duration of noninvasive ventilation longer than 12 hours
- Preserved consciousness with Glasgow Coma Scale score of 13 or higher
You will not qualify if you...
- Use of noninvasive ventilation for more than 24 hours before randomization
- Acute-on-chronic respiratory failure
- Congestive heart failure
- Use of noninvasive ventilation after extubation within 48 hours
- Contraindications to noninvasive ventilation, such as anatomical malformations or recent pulmonary/esophageal surgery within 7 days
- Presence of pneumothorax
- Intolerance to noninvasive ventilation
- Refusal to participate
- Pregnancy
- Need for emergency intubation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
Actively Recruiting
Research Team
M
Mengyi Ma
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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