Randomized Trial of High Phenolic Extra Virgin Olive Oil for Adults with Overweight or Obesity and Metabolic Problems

What this Trial Is About

Researchers are investigating how high-phenolic extra virgin olive oil affects metabolic health in adults with overweight or obesity and related metabolic abnormalities. This study compares the effects of consuming olive oil rich in phenolic compounds to olive oil with low phenolic content. The research focuses on how these oils may influence markers related to obesity, metabolic health, and quality of life over an eight-week period. Participants will be randomly assigned to consume either high phenolic olive oil HPOO containing over 1000 mgkg total polyphenols or low phenolic olive oil LPOO with 100 mgkg or less. Each person will take an amount tailored to their fat energy needs to encourage mild weight loss. Both groups receive dietary guidance for mild weight loss and olive oil is provided every two weeks in identical containers to maintain blinding. Throughout the study, participants will visit the research center at the start and after eight weeks for measurements including body composition, blood pressure, metabolic rate, and blood tests for lipids, glucose, hormones, and inflammation markers. Questionnaires will assess diet, physical activity, sleep quality, mood, and quality of life. Compliance and dietary habits will be monitored by phone every two weeks, and safety and data privacy protections are strictly followed.

High Phenolic Olive Oil for Enhancing Metabolic Health: a Randomized-controlled Trial in Patients With cEntral Obesity (HOPE)