Actively Recruiting
High Phenolic Olive Oil for Enhancing Metabolic Health: a Randomized-controlled Trial in Patients With Central Obesity
Led by University of Peloponnese · Updated on 2026-03-03
80
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
Sponsors
U
University of Peloponnese
Lead Sponsor
H
Harokopio University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how high-phenolic extra virgin olive oil affects metabolic health in adults with overweight or obesity and related metabolic abnormalities. This study compares the effects of consuming olive oil rich in phenolic compounds to olive oil with low phenolic content. The research focuses on how these oils may influence markers related to obesity, metabolic health, and quality of life over an eight-week period. Participants will be randomly assigned to consume either high phenolic olive oil (HPOO) containing over 1000 mg/kg total polyphenols or low phenolic olive oil (LPOO) with 100 mg/kg or less. Each person will take an amount tailored to their fat energy needs to encourage mild weight loss. Both groups receive dietary guidance for mild weight loss and olive oil is provided every two weeks in identical containers to maintain blinding. Throughout the study, participants will visit the research center at the start and after eight weeks for measurements including body composition, blood pressure, metabolic rate, and blood tests for lipids, glucose, hormones, and inflammation markers. Questionnaires will assess diet, physical activity, sleep quality, mood, and quality of life. Compliance and dietary habits will be monitored by phone every two weeks, and safety and data privacy protections are strictly followed.
CONDITIONS
Brief Title
High Phenolic Olive Oil for Enhancing Metabolic Health: a Randomized-controlled Trial in Patients With cEntral Obesity (HOPE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult men and women 18 to 80 years old
- Overweight or obesity with BMI over 25 or waist circumference over 94 cm for men and over 80 cm for women
- Presence of at least one metabolic abnormality: triglycerides 6150 mg/dL or low HDL cholesterol (40 mg/dL men, 50 mg/dL women), high blood pressure (130/85 mm Hg), elevated fasting blood sugar (100 mg/dL), or standardized drug treatment
- Signed informed consent for participation
You will not qualify if you...
- Acute or chronic diseases such as infection, cancer, chronic heart failure, kidney disease, autoimmune diseases, or inflammatory bowel diseases
- Untreated diabetes
- Women who are pregnant or breastfeeding
- Psychiatric or mental disorders
- Use of antioxidant-phytochemical rich supplements or anti-, pre-, or probiotics before the study
- Drug or alcohol abuse
- Unable or unwilling to provide consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for eligibility assessment
Duration - 8 weeks
Participants consume either high phenolic olive oil or low phenolic olive oil daily, accompanied by standardized dietary guidance for mild weight loss.
1 baseline visit and 1 follow-up visit at 8 weeks; telephone follow-ups every 2 weeks
Trial Site Locations
Total: 1 location
1
Antikalamos Facilities of University of Peloponnese
Kalamata, Greece, 24100
Actively Recruiting
Research Team
A
Aristea Gioxari, Assistant Professor
A
Alexandra Foscolou, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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