Actively Recruiting
High Resolution Gastric Mapping and Gastroduodenal Manometry
Led by Mayo Clinic · Updated on 2025-08-19
100
Participants Needed
1
Research Sites
76 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Dyspepsia is a common problem attributed to gastric sensorimotor dysfunctions ie, delayed, or less frequently rapid gastric emptying (GE), impaired gastric accommodation, and increased gastric sensation. Therapeutic options manage symptoms, and there is no FDA approved medical therapy for dyspepsia. There is a need for better objective understanding of sensorimotor dysfunction in dyspepsia, as well as noninvasive, efficacious, safe, and inexpensive treatments for dyspepsia. The purpose of this research is to identify disturbances and characterize phenotypes in patients with functional dyspepsia, and to assess the correlations between symptoms (during the manometry and in daily life), gastric emptying, electrical activity (BSGM), and pressure activity (manometry).
CONDITIONS
Official Title
High Resolution Gastric Mapping and Gastroduodenal Manometry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Symptoms consistent with functional dyspepsia as defined by the ROME IV criteria for 6 months
- Ability to perform appropriate informed consent
You will not qualify if you...
- Known cardiac arrhythmia or major ECG abnormalities, including 2nd or 3rd degree AV block, prolonged QTc interval (> 460 msec), or bradycardia (< 45 beats/minute)
- Conditions that prevent safe use of transcutaneous auricular vagal nerve stimulation (taVNS)
- Significant cardiovascular, respiratory, renal, hepatic, gastrointestinal, hematological, neurological, psychiatric or other diseases that may interfere with study objectives or pose safety concerns
- Use of opioids
- Vulnerable study population
- Pregnant women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
S
Shelly L Ward
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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