Study of Gastric Function in Adults with Dyspepsia Using High Resolution Gastric Mapping, Gastroduodenal Manometry, and Gastric Emptying Tests with Ear Nerve Stimulation

What this Trial Is About

Dyspepsia is a common digestive problem linked to abnormal stomach movements such as delayed or rapid gastric emptying, impaired stomach relaxation, and increased stomach sensitivity. Researchers aim to better understand these dysfunctions by identifying specific patterns and symptoms in patients with functional dyspepsia, and by exploring how symptoms relate to stomach emptying, electrical activity, and pressure changes. This study is conducted by Mayo Clinic to improve objective knowledge and find safe, noninvasive treatment options for dyspepsia. Participants will undergo evaluations using devices that measure electrical activity of the stomach body surface gastric mapping, BSGM and pressure inside the stomach and duodenum gastroduodenal manometry. Some participants will receive transcutaneous auricular vagal nerve stimulation taVNS, a form of electrical stimulation applied to the ear, during these assessments. One group will have both manometry and BSGM with taVNS applied during the study, while another group will undergo only BSGM followed by taVNS intervention. During the approximately 8-hour motility studies, researchers will monitor stomach and duodenal contraction frequency, amplitude, pressure activity, and electrical rhythm using the devices. Participants will be observed for correlations between symptoms experienced during testing and daily life. The study includes careful monitoring of physiological responses and symptom assessments to characterize gastric function and the effects of taVNS. Total participation time varies per individual, with no masking or randomization involved.

High Resolution Gastric Mapping and Gastroduodenal Manometry