Study of Esophageal Movement Changes After Partial Fundoplication Surgery for Acid Reflux

What this Trial Is About

This research evaluates esophageal motility changes in patients undergoing laparoscopic partial fundoplication 180 anterior or 270 posterior for gastroesophageal reflux disease GERD who have preoperative ineffective esophageal motility IEM. The study is combined retro- and prospective and focuses on whether postoperative motility decreases compared to preoperative levels, based on the hypothesis that motility disorders are caused by reflux. Participants who had or will have partial fundoplication between 2020 and 2023 are assessed for preoperative IEM. Those with IEM are invited to undergo high-resolution manometry 18 to 24 months after surgery to examine postoperative motility. The study also compares other motility disorders and evaluates gastrointestinal symptoms using the Gastrointestinal Symptom Rating Scale GSRS before and after surgery. During the study, participants provide consent and undergo high-resolution manometry, an outpatient diagnostic test where a thin catheter measures esophageal pressures during swallowing. The GSRS questionnaire is completed pre- and postoperatively as part of routine care. The primary outcome measures the persistence of IEM one to two years after surgery, with secondary outcomes including other motility disorders and symptom changes. The study duration extends through December 2027.

High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux