Exploratory Pilot Study of High-Resolution PET-CT Imaging of Removed Tumors During Surgery to Check Complete Removal

What this Trial Is About

This research aims to improve the surgical treatment of patients with benign or malignant tumors that require removal. The study evaluates the use of high-resolution PET-CT imaging on tissue specimens removed during surgery to better visualize the tumor margins. The goal is to see if this imaging method can help confirm complete tumor removal during surgery, potentially reducing the need for additional treatments, shortening treatment times, and lowering emotional stress and costs for patients. This is an exploratory pilot study including various tumor types such as breast, prostate, thyroid, skin, hepatobiliary, and others. Participants will receive a single intravenous injection of a radiotracer before surgery, with the type and dose adjusted based on their specific tumor group. After the tumor is removed, the specimen is scanned using a specialized high-resolution PET-CT scanner in the operating room. While no treatment decisions are generally made based on these images, the surgeon may decide to remove additional tissue if needed. The study also compares these images with standard preoperative imaging to assess visualization differences. During the study, participants will undergo surgery as part of their treatment, with the added PET-CT specimen imaging performed during the operation. Researchers will collect data on the correlation between imaging results and microscopic histopathological analysis of tumor margins up to two weeks after surgery. They will also compare the perioperative images with preoperative scans. This study includes assessments of radiation safety and aims to gather scientific knowledge on the clinical usefulness of this imaging technique across various tumor types. Participation duration depends on surgical and follow-up timelines, ending around two weeks after surgery when pathology results are reviewed.

High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins