Actively Recruiting
At High-risk for Pre-eclampsia After Assisted Reproductive Technology
Led by CRG UZ Brussel · Updated on 2023-03-28
1050
Participants Needed
1
Research Sites
241 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overarching goal of the project is to unravel PE etiopathogenesis in high-risk patients (PCOS patients and oocyte acceptors) after assisted reproductive technology (ART) to individualize prenatal care following ART and to determine potential targets for new PE prevention options decreasing the morbidity/mortality caused by this pathology. More specifically, the following objectives/work packages (WPs) are put forward: * WP1 - PRECONCEPTION: Identify preconceptional maternal characteristics associated with in-creased risk of PE in ART patients (1a) and investigate the potential role of the endometrium prior to pregnancy (1b). * WP2 - DURING PREGNANCY: Evaluate the Fetal Medicine Foundation's (FMF) first trimester PE screening in selected high-risk groups post ART to explore the clinical benefit in this specific context (2a) and investigate the association between parameters during the pregnancy and PE development post-ART. * WP3 - AT DELIVERY: Identifying placental molecular pathways associated with PE post-ART.
CONDITIONS
Official Title
At High-risk for Pre-eclampsia After Assisted Reproductive Technology
Who Can Participate
Eligibility Criteria
You may qualify if you...
- First-time oocyte recipients or nulliparous PCOS patients undergoing ART (IVF/ICSI)
- Diagnosis of PCOS requires two of the following: menstrual cycles longer than 35 days; clinical signs of hirsutism or severe acne with alopecia or biochemical evidence of high testosterone; polycystic ovaries with specific ultrasound or AMH criteria
You will not qualify if you...
- Known essential hypertension or new-onset hypertension before 20 weeks' gestation
- Known type 1 or type 2 diabetes before pregnancy
- Uncontrolled thyroid dysfunction (hyperthyroidism or hypothyroidism)
- Other endocrinological disorders such as Cushing syndrome, adrenal insufficiency, or acromegaly
- Cardiovascular diseases including coronary artery disease, arrhythmia, heart valve disease, or heart failure
- Renal disease or insufficiency
- Systemic lupus erythematosus
- Antiphospholipid syndrome
- Liver dysfunction or disease
- History of prior pre-eclampsia
- Pregnant with fetus having known abnormalities like chromosomal anomalies or structural deformities
- Multiple pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brussels IVF
Brussels, Belgium, 1090
Actively Recruiting
Research Team
S
Study nurses Brussels IVF
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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