Actively Recruiting
HIIT Following Breast Cancer Chemotherapy
Led by University of Florida · Updated on 2025-11-21
158
Participants Needed
1
Research Sites
116 weeks
Total Duration
On this page
Sponsors
U
University of Florida
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Chemotherapy is an effective breast cancer treatment, which helped to increase the 5-year survival rate to approximately 95%. However, breast cancer survivors have a higher risk of cardiovascular disease (CVD) due to chemotherapy than adults without cancer. Cardiovascular rehabilitation can be an effective strategy to decrease the incidence of CVD and its risk factors in this population. The proposed study may help to examine the effect and durability of a novel high-intensity interval training compared to moderate-intensity continuous training on cardiovascular rehabilitation in breast cancer survivors.
CONDITIONS
Official Title
HIIT Following Breast Cancer Chemotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients based on biological sex
- Age between 18 and 85 years
- Diagnosis of primary, invasive, non-metastatic, stages I-III breast cancer
- Completed chemotherapy for breast cancer (anthracycline, alkylating agent and/or taxane) more than 6 months but less than 18 months prior to study enrollment
- Adjuvant endocrine therapy, CDK4/6 inhibitors, PARP inhibitors, HER2 targeted agents, immunotherapy, and bisphosphonates allowed within 6 months before and during study
- No contraindications to exercise or study participation
- Approval by study clinician
You will not qualify if you...
- Not meeting inclusion criteria
- Scheduled for surgery or radiation therapy during the intervention period
- Any relevant cardiovascular diseases (stroke, heart failure, myocardial ischemia during maximal graded exercise test, myocardial infarction, angina pectoris, coronary artery bypass surgery, angioplasty, or coronary stent)
- Lymphedema stage 2 or higher before enrollment
- Pregnancy
- Current participation in other experimental interventions that could affect study results (e.g., dietary intervention for weight loss)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Integrative Cardiovascular Physiology Laboratory, University of Florida
Gainesville, Florida, United States, 32611
Actively Recruiting
Research Team
D
Demetra Christou, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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