Actively Recruiting
Hip Fracture Surgery Timing and Blood Transfusion Risk in Patients on DOACs
Led by St. Antonius Hospital · Updated on 2025-12-30
374
Participants Needed
7
Research Sites
112 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study looks at patients with hip fractures who are taking direct oral anticoagulants (DOACs), a type of blood thinner. In many hospitals, surgery for these patients is delayed because of concerns about bleeding, but waiting longer can also increase risks such as complications and longer hospital stays. The purpose of this study is to find out whether operating within 24 hours is as safe as delaying surgery beyond 24 hours. Specifically, the investigators want to know if early surgery does not lead to a higher need for blood transfusions compared to delayed surgery.
CONDITIONS
Official Title
Hip Fracture Surgery Timing and Blood Transfusion Risk in Patients on DOACs
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Isolated hip fracture classified as AO/OTA 31A or 31B requiring surgical intervention.
- Current use of direct oral anticoagulants (DOACs) with the last dose taken within 24 hours before emergency department presentation.
You will not qualify if you...
- Pathologic or periprosthetic hip fractures.
- Fracture sustained more than 24 hours before emergency department presentation.
- Inter-hospital transfer.
- Hematologic disorders such as thalassemia, sickle cell disease, aplastic anemia, myelodysplastic syndromes, or leukemia.
- Use of a non-European Medicines Agency (EMA) approved DOAC (e.g., betrixaban).
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Ziekenhuisgroep Twente Hospital
Almelo, Netherlands
Actively Recruiting
2
Onze Lieve Vrouw Gasthuis Hospital
Amsterdam, Netherlands
Actively Recruiting
3
Rijnstate Hospital
Arnhem, Netherlands
Actively Recruiting
4
Deventer Hospital
Deventer, Netherlands
Actively Recruiting
5
Martini Hospital
Groningen, Netherlands
Actively Recruiting
6
Diakonessenhuis Hospital
Utrecht, Netherlands
Actively Recruiting
7
St. Antonius Hospital
Utrecht, Netherlands
Actively Recruiting
Research Team
T
Tim Schiepers, MD
CONTACT
H
Henk Jan Schuijt, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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