Actively Recruiting
Hippocampal Oscillations During Exploration
Led by NYU Langone Health · Updated on 2026-02-27
56
Participants Needed
1
Research Sites
136 weeks
Total Duration
On this page
Sponsors
N
NYU Langone Health
Lead Sponsor
N
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.
CONDITIONS
Official Title
Hippocampal Oscillations During Exploration
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 70 years
- Able to provide informed consent
- Surgical epilepsy patients with implanted hippocampal depth electrodes for Stage 1 epilepsy surgery
- IQ of 80 or higher for surgical patients
- Epilepsy patients with implanted responsive neurostimulator (RNS) device including at least one hippocampal depth electrode
- At least 5 months post-implantation for RNS patients
- RNS patients have no more than 1 debilitating seizure per week
- Able to walk and wear research equipment without assistance (RNS patients and healthy controls)
- IQ of 80 or higher for RNS patients
- Healthy controls able to walk and wear research equipment without assistance
You will not qualify if you...
- Any generalized tonic-clonic seizures within the last year for RNS patients
- Legally blind
- Use of tobacco, marijuana, recreational drugs, or alcohol within 1 week of cognitive testing
- Unable to give informed consent
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
Research Team
A
Anli Liu, MD, MA
CONTACT
A
Ayelet Rosenberg
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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