Investigation of the Relationship Between Hippocampal Volume and Memory Functions in Patients With Aneurysmal Subarachnoid Hemorrhage

What this Trial Is About

This research aims to explore the long-term effects on memory and brain structure in patients who have experienced aneurysmal subarachnoid hemorrhage (aSAH). It focuses on understanding if the common memory problems observed after aSAH are linked to shrinkage of the hippocampus, a key brain area involved in memory. The study addresses a gap where memory deficits appear even without clear brain damage on standard imaging. Participants include neurological rehabilitation patients with aSAH of mild to moderate severity (Hunt & Hess grade I or II) within 24 months after their event. Early after enrollment, participants undergo a high-resolution MRI scan to measure hippocampal volume and receive detailed neuropsychological testing to assess memory and attention function. The study also includes a comparison group of healthy adults matched by age, gender, and education. Throughout the study, detailed brain imaging and cognitive tests are performed to measure changes in hippocampal size and memory abilities around two weeks after enrollment. Researchers will examine how therapy types and specific brain lesion locations influence these outcomes. The study monitors data quality carefully and assesses interrater reliability to ensure accurate measurement. Participation may last over a period that includes initial MRI and neuropsychological assessments during neurological rehabilitation.

Hippocampal Volume and Memory Functions in Aneurysmal Subarachnoid Hemorrhage