Actively Recruiting
Histamines and Central Hemodynamics
Led by University of British Columbia · Updated on 2025-12-23
20
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
When we exercise, more blood flow goes to our muscles, challenging our blood vessels. Following exercise, blood flow remains elevated and seems to be the reason for many of the positive cardiovascular benefits that occur with exercise. When the actions of histamine, a molecule primarily known for its role in allergies, are blocked, there is an attenuated blood flow response following exercise. However, this effect has never been studied in the blood vessels that supply our lungs. The purpose of this study is to examine the effects of histamines on pulmonary hemodynamics following exercise.
CONDITIONS
Official Title
Histamines and Central Hemodynamics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 19 and 39 years
- Willing to visit the lab on 3 separate occasions
You will not qualify if you...
- Previously diagnosed heart condition
- Previously diagnosed lung condition (including asthma)
- Previously diagnosed metabolic condition
- Current smoker or smoked cigarettes, electronic cigarettes, or cannabis within the last 3 months
- Resting blood pressure greater than 140/90 mmHg
- Unable to obtain appropriate quality ultrasound images of the heart
- No tricuspid regurgitation at rest to allow assessment of the primary outcome
- Pregnant or trying to become pregnant
- Breastfeeding
- Chronically take antihistamines daily
- History of adverse reactions to antihistamines
- Never taken antihistamines previously
- Currently taking any medications, including oral contraceptives
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of British Columbia
Kelowna, British Columbia, Canada, V1V2L2
Actively Recruiting
Research Team
N
Neil Eves, PhD
CONTACT
C
Cassidy Williams, BHK
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here