Actively Recruiting
Hitting the Mark: Introducing State-of-the-art MRI for Precision Radiotherapy of Glioblastoma
Led by Erasmus Medical Center · Updated on 2025-06-12
53
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this prospective cohort study is to assess the potential of advanced MRI for improved radiotherapy target delineation in patients diagnosed with glioblastoma. The main questions it aims to answer are: * How does the coverage of the recurrence volume by a radiotherapy plan based on advanced MRI compare to the coverage by the clinical radiotherapy plan? * How does the distribution of the dose to organs at risk by a radiotherapy plan based on advanced MRI compare to the distribution by the clinical radiotherapy plan? Participants will undergo an extended MRI-protocol prior to radiotherapy. This extended MRI-protocol includes the clinical brain tumor imaging protocol plus additional advanced MRI-sequences. Radiation treatment and patient follow-up will occur according to the clinical standard.
CONDITIONS
Official Title
Hitting the Mark: Introducing State-of-the-art MRI for Precision Radiotherapy of Glioblastoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provided written informed consent
- Adult aged 18 years or older
- Diagnosed with IDH-wildtype glioblastoma confirmed by pathology including molecular analysis after surgery or biopsy
- Referred to the Department of Radiotherapy outpatient clinic for standard radiotherapy treatment (30x2 Gy, 15x2.67 Gy, or 10x3.4 Gy)
You will not qualify if you...
- Contraindication for 3 Tesla MRI
- Contraindication for gadolinium-based contrast agent, such as renal deficiency or known allergy
- Referred for treatment of recurrent glioblastoma
- Previous radiotherapy to the brain
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Erasmus Medical Center
Rotterdam, South Holland, Netherlands, 3015GD
Actively Recruiting
Research Team
P
Patrick Tang, MSc
CONTACT
R
René Vernhout, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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