Actively Recruiting
HN-QUEST: A Study of Head and Neck Imaging Biomarkers
Led by University Health Network, Toronto · Updated on 2026-03-05
173
Participants Needed
1
Research Sites
309 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multi arm, single center, investigator initiated study to investigate online adaptive radiotherapy and biomarker development in patients with newly diagnosed HNSCC (Head and Neck Squamous Cell Carcinoma) receiving curative therapy. The study will consist of two prospective arms. In Arm 1 up to 100 HNSCC patients receiving (CT)RT (computed tomography-based radiation therapy) will receive up to weekly non-contrast MRI (magnetic resonance imaging) scans during treatment. Arm 2 consists of two cohorts. In cohort A up to 20 healthy volunteers will undergo non-contrast MRI at two time points. In cohort B up to 53 patients planned to receive curative (chemo) radiotherapy for HNSCC will undergo two baseline MRI scans, one MRI in week 2 and week 4, and final MRI scan 6-8 weeks after completion of treatment.
CONDITIONS
Official Title
HN-QUEST: A Study of Head and Neck Imaging Biomarkers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Histologically confirmed Head and Neck Squamous Cell Carcinoma
- Primary or nodal tumor size greater than 3 cm for biomarker imaging
- Eastern Cooperative Oncology Group (ECOG) Performance Status between 0 and 2
- Planned to receive curative surgery or (chemo)radiotherapy
- Willing to undergo repeat MRI scans
- Able to understand study information and provide written informed consent
- Adequate kidney function with creatinine clearance at least 30 ml/min
- Able to lie comfortably on back for 1 hour
- For healthy volunteers: age 18 years or older
- For healthy volunteers: able to understand study information and provide written informed consent
- For healthy volunteers: willing to undergo repeat MRI scans
You will not qualify if you...
- Evidence of systemic disease making participation unsuitable as judged by investigator
- Contraindications to serial MRI scans
- Previous solid tumor treated within the last 5 years
- Pregnancy
- History of significant obstructive airway disease
- Allergy to gadolinium contrast
- For healthy volunteers: unwillingness to sign informed consent
- For healthy volunteers: contraindications to MRI
- For healthy volunteers: underlying significant respiratory disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 1X6
Actively Recruiting
Research Team
R
Rehab Chahin, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here