Comparing Thulium and Holmium Laser Surgery for Enlarged Prostate in Men A Study on Urinary Symptoms and Recovery After Prostate Surgery

What this Trial Is About

Benign prostatic hyperplasia BPH is a common condition in older men where an enlarged prostate causes urinary problems such as weak stream, frequent urination, and incomplete bladder emptying. This trial evaluates two laser surgery techniques, Holmium Laser Enucleation of the Prostate HoLEP and Thulium Laser Enucleation of the Prostate ThuLEP, to see if ThuLEP is as effective as HoLEP in improving urinary symptoms and to compare recovery and complication rates. The study is a prospective, randomized, single-blind trial involving men with clinically relevant BPH who need surgery. Participants will be randomly assigned to either the ThuLEP or HoLEP procedure. Both are established surgical treatments using laser energy to remove enlarged prostate tissue, with ThuLEP using a pulsed thulium laser and HoLEP using a holmiumYAG laser. Surgery is performed following standard procedures, and participants are unaware of which technique they receive. After surgery, follow-up visits will occur at discharge and at 3, 6, and 12 months, where various health measures are assessed. Throughout the study, participants complete questionnaires on urinary symptoms, continence, and erectile function, and undergo tests such as uroflowmetry and residual urine measurement before surgery and during follow-up visits. Researchers monitor operative details, complications, and the need for further interventions over 12 months. The main outcome is the change in urinary symptoms measured by the International Prostate Symptom Score IPSS at 12 months after surgery.

HoLEP-ThuLEP - Comparing Lasers for BPH Surgery