Actively Recruiting
Holy Basil in The Treatment of Dyspepsia
Led by Mahidol University · Updated on 2026-03-24
27
Participants Needed
1
Research Sites
41 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate whether holy basil extract can reduce gastric inflammation and improve symptoms in adult patients with dyspepsia. The main questions it aims to answer are: * Does holy basil extract reduce gastric mucosal inflammation as measured by histopathology? * Does holy basil extract improve dyspeptic symptoms, endoscopic findings, gastric pH, duodenal eosinophil counts, and systemic inflammation (serum IL-6)? Participants will: * Take 300 mg of holy basil extract orally once daily for 28 days * Complete symptom questionnaires and diaries during treatment * Undergo upper endoscopy with biopsy and intragastric pH monitoring before and after treatment * Provide blood samples for inflammatory marker measurement * Be monitored for safety and adverse events
CONDITIONS
Official Title
Holy Basil in The Treatment of Dyspepsia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 years and older.
- Presence of dyspeptic symptoms with a Leeds Dyspepsia Questionnaire score of at least 5.
You will not qualify if you...
- Presence of Helicobacter pylori infection.
- Diagnosis of peptic ulcer or erosive esophagitis Los Angeles Classification grade B or greater.
- Use of acid-suppressant therapy including proton pump inhibitors or histamine-2 receptor antagonists that cannot be stopped at least 2 weeks before and during the study.
- Use of mucosal protective agents such as rebamipide, sucralfate, or irsogladine that cannot be stopped at least 4 weeks before and during the study.
- History of gastric or duodenal cancer.
- Previous upper gastrointestinal surgery.
- Current pregnancy or breastfeeding.
- Known allergy to the study medicine.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok Noi, Bangkok, Thailand, 10700
Actively Recruiting
Research Team
M
Monthira Maneerattanaporn, MD
CONTACT
P
Pubet Weeranawin, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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