Actively Recruiting
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
Led by Hebrew SeniorLife · Updated on 2025-09-22
128
Participants Needed
2
Research Sites
195 weeks
Total Duration
On this page
Sponsors
H
Hebrew SeniorLife
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function, dual task standing and walking, and other metrics of mobility in older adults with motoric cognitive risk syndrome (MCR).
CONDITIONS
Official Title
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women
- Age 65-90 years
- Subjective cognitive complaints defined by specific memory or mental clarity questions
- Montreal Cognitive Assessment (MoCA) score of 21 or higher
- Slow gait speed measured by averaging two 4-Meter walks, one standard deviation below age and sex norms
- Ability to walk unassisted on an instrumented gait mat for at least 2 minutes without walking aids
- Preserved activities of daily living with a Functional Activities Questionnaire score less than 9
- Identification of an eligible informant
- Identification of a willing and able study partner to assist with home-based tDCS administration
- Access to reliable WiFi in the participant's home
You will not qualify if you...
- Less than 8th grade formal education
- Previous physician diagnosis of dementia
- Current diagnosis of major psychiatric disorders such as schizophrenia, bipolar disorder, or major depressive disorder
- Moderate-to-severe depressive symptoms defined by a score of 9 or higher on the 15-item Geriatric Depression Scale
- History of head trauma with prolonged loss of consciousness
- History of unexplained fainting spells that might be seizures
- History of seizures, epilepsy, or immediate family history of epilepsy except for benign single seizures
- Hospitalization in the past 3 months due to acute illness or musculoskeletal injury affecting gait or balance
- Any unstable or uncontrolled medical condition that may cause emergencies or study complications
- Substance use disorders within the past 6 months
- Hairstyles or head coverings preventing electrode contact with the scalp (e.g., thick braids, hair weave, afro, wig)
- Chronic vertigo
- Myocardial infarction within the past 6 months
- Active cancer receiving chemotherapy or radiation
- Legal blindness
- Visual hallucinations
- Presence of a pacemaker
- Contraindications to MRI or tDCS including unprovoked seizures within the past 2 years, implanted medical devices, active scalp skin conditions
- History of REM sleep behavior disorder
- Medication and medical history reviewed by physician to confirm eligibility based on drug use and CNS-active medications
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Hebrew Rehabilitation Center
Roslindale, Massachusetts, United States, 02131
Actively Recruiting
2
Tel Aviv Sourasky Medical Center
Tel Aviv, Israel
Actively Recruiting
Research Team
K
Katie Baldyga, BA
CONTACT
J
Juhi Salecha, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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