Actively Recruiting
Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS)
Led by NYU Langone Health · Updated on 2025-08-14
170
Participants Needed
1
Research Sites
146 weeks
Total Duration
On this page
Sponsors
N
NYU Langone Health
Lead Sponsor
N
National Multiple Sclerosis Society
Collaborating Sponsor
AI-Summary
What this Trial Is About
This project is a double-blind, sham-controlled, parallel-arm, randomized controlled trial. We will recruit n=170 people living with MS, who are experiencing an episode of depression in the context of a major depressive episode (MDE). Using our remotely supervised (RS) tDCS protocol, enrolled participants will complete 30 days of 30-minute tDCS (2.0, DLPFC left anodal) while listening to mindfulness meditation. Over the course of the study, participants will complete assessments of depression and MS symptoms. Participants will be randomized 1:1 active:sham tDCS.
CONDITIONS
Official Title
Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 65 years inclusive
- Confirmed diagnosis of multiple sclerosis (MS), including relapsing-remitting or secondary progressive subtypes
- Stable use of antidepressant and disease-modifying therapies for at least 30 days prior to enrollment
- No clinical relapse, new radiological disease activity, or steroid treatment for at least 30 days prior to enrollment
- Access to a local provider responsible for clinical care and available if needed due to depressive symptoms
- Ability to use mobile devices and participate in remote, video-supervised sessions
You will not qualify if you...
- History of neurological disorders other than MS (e.g., stroke, Parkinson's disease, traumatic brain injury, intracranial mass, epilepsy, mild cognitive impairment, dementia)
- Major psychiatric disorders such as bipolar disorder or psychotic disorders
- Serious medical conditions including myocardial infarction, thyroid disease, or diabetes with complications
- Nicotine use (smoking or vaping) within the past 6 months
- Currently pregnant, planning pregnancy during the study, or breastfeeding
- History of seizures or seizure disorder within the past 5 years
- Presence of metal in head/neck area (excluding dental fillings) or implanted medical devices like pacemakers
- Active skin disorders or sensitivity near electrode sites
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
NYU Langone Health
New York, New York, United States, 10017
Actively Recruiting
Research Team
S
Shayna Pehel
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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