Actively Recruiting
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Led by Mayo Clinic · Updated on 2026-04-20
220
Participants Needed
2
Research Sites
175 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial studies the effect of cancer directed therapy given at-home versus in the clinic for patients with cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Currently most drug-related cancer care is conducted in infusion centers or specialty hospitals, where patients spend many hours a day isolated from family, friends, and familiar surroundings. This separation adds to the physical, emotional, social, and financial burden for patients and their families. The logistics and costs of navigating cancer treatments have become a principal contributor to patients' reduced quality of life. It is therefore important to reduce the burden of cancer in the lives of patients and their caregivers, and a vital aspect of this involves moving beyond traditional hospital and clinic-based care and evaluate innovative care delivery models with virtual capabilities. Providing cancer treatment at-home, versus in the clinic, may help reduce psychological and financial distress and increase treatment compliance, especially for marginalized patients and communities.
CONDITIONS
Official Title
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients with confirmed cancer diagnosis or imaging diagnosis of hepatocellular carcinoma
- Receiving standard-of-care treatment regimen approved or recommended by national guidelines
- Receiving one of the specified eligible cancer types and treatment regimens
- Adequate tolerability of current cancer treatment without drug-related infusion reactions
- Plan to continue current treatment for at least 24 weeks after randomization
- Living within the service area of the home health and paramedic network
- Residence has wifi or suitable wireless network connection
- Age 18 years or older at registration
- Signed informed consent
- Able and willing to follow the study protocol
- Eastern Cooperative Oncology Group Performance Status of 0, 1, or 2
- Ability to complete study questionnaires alone or with help
- Confirmation of tolerability and no infusion reactions prior to randomization
You will not qualify if you...
- Receiving other investigational cancer treatments outside the study protocol
- Needing 24/7 help with daily living activities
- Currently hospitalized as an inpatient (except Advanced Care at Home program)
- Severe or uncontrolled medical illnesses that interfere with study safety or assessments
- Active infections or unstable heart conditions including recent heart attack
- Wound healing problems
- Psychiatric or social issues limiting study compliance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224-9980
Actively Recruiting
2
Altru Cancer Center
Grand Forks, North Dakota, United States, 58201
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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