Randomized Study Comparing At-Home Versus In-Clinic Cancer Treatment for Adults with Advanced Cancer

What this Trial Is About

Researchers are evaluating the effects of delivering cancer-directed therapy at home versus in a clinic for patients with advanced cancer that has spread beyond its original site. This trial aims to reduce the physical, emotional, social, and financial burdens of cancer treatment, which often requires long visits to infusion centers or specialty hospitals. By exploring virtual care models, the study seeks to improve quality of life and treatment adherence, especially for marginalized patients and communities. Participants first receive at least one cycle of their standard cancer treatment in the clinic. They are then randomly assigned to one of two groups one group continues treatment at home for about 24 weeks with support from a home health nurse and a remote Command Center, including health monitoring devices and video visits. The other group receives about 8 weeks of treatment in the clinic before switching to home treatment for an additional 16 weeks under the same home health program. During the study, patients undergo routine lab tests, drug infusions, and health monitoring either at home or in the clinic. Researchers collect patient feedback on access to care, treatment preferences, comfort levels, quality of life, symptoms, and safety through questionnaires and monitoring tools. They also track adverse events, emergency visits, hospitalizations, and overall survival. After completing treatment, participants are followed for one year to assess longer-term outcomes.

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer