Actively Recruiting
At-Home Cardiac Rehabilitation for Adolescents at Risk for Heart Failure
Led by Children's Hospital Los Angeles · Updated on 2025-02-14
20
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are exploring how an at-home cardio-oncology rehabilitation (CORE) program may affect short-term heart fitness and mental wellness in adolescent cancer survivors. This study aims to evaluate the benefits of exercise and lifestyle changes in young people at risk for heart failure after cancer treatment. It also seeks to understand how well participants stick to exercise routines and which resources help them maintain healthy habits. The study is led by Children's Hospital Los Angeles and focuses on improving cardiovascular health and quality of life over six months. Participants will follow a CORE program involving at least 60 minutes of daily physical activity, including vigorous exercise and strength training three times a week. The study lasts six months, during which participants receive exercise and dietary guidance. Monthly virtual check-ins will support adherence to the program. Participants will wear a Fitbit device and keep a diary to track their activity and progress. Before starting, participants undergo cardiovascular tests and complete quality-of-life surveys. These assessments are repeated at the end of the six months to measure changes in heart function, heart rhythm, cardiac stress, cholesterol levels, and overall fitness. Researchers will also evaluate improvements in lifestyle habits and activity levels. The study includes regular monitoring through surveys and virtual visits to support participant engagement and safety.
CONDITIONS
Brief Title
At-Home Cardiac Rehabilitation for Adolescents at Risk for Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 10 to 21 years at enrollment
- Parent or legal guardian available for consent if applicable, and patient available for assent and consent
- History of anthracycline exposure with or without radiation
- Currently in remission and at least 6 months off chemotherapy
- Able to perform cardiopulmonary exercise testing (CPET)
- Baseline CPET with VO2 less than 80% at start of study or CPET at CHLA after January 2020
- Owns or has access to a smartphone compatible with Fitbit
- Ability to complete and send diary and Fitbit data weekly
- Ability to participate in monthly virtual check-in visits
- Baseline activity less than 30 minutes per day, 2 times per week prior to intervention
You will not qualify if you...
- Unable to provide consent or assent
- Unable to perform quality of life survey independently
- Presence of other primary medical diagnoses such as Down Syndrome, Wolff-Parkinson-White Syndrome, or congenital heart disease
- History of cardiothoracic surgery
- Contraindications to moderate activity above 3 METs, including malignant arrhythmias, exercise-induced syncope, or severe heart failure symptoms (NYHA IV, ACC/AHA Stage D)
- Unable to perform CPET, echocardiogram, EKG, or lab studies
- Unable to perform mild activity for at least 30 minutes per day, 2 times per week
- Unable to attend hospital visits at 0 and 6 months
- Unable to complete study-related surveys
- Unable to submit diary and Fitbit data weekly
- Unable to participate in monthly virtual check-ins
- Currently taking beta blockers
- Pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 months
Participants engage in at-home cardiac rehabilitation involving at least 60 minutes of physical activity each day, including vigorous-intensity and strengthening activities at least 3 days per week.
Monthly virtual check-in visits
Trial Site Locations
Total: 1 location
1
Children's Hospital Los Angeles
Los Angeles, California, United States, 90027
Actively Recruiting
Research Team
O
Obdulio Carreras
J
Jennifer Su, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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