Actively Recruiting
Home High Flow Oxygen to Reduce Acute Exacerbation of COPD
Led by University Hospital, Rouen · Updated on 2026-02-06
406
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of the study is to evaluate the efficacy of home High Flow Oxygen for the reduction of severe exacerbation following admission for a severe exacerbation of COPD or death against standard oxygen therapy.
CONDITIONS
Official Title
Home High Flow Oxygen to Reduce Acute Exacerbation of COPD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of COPD according to GOLD guidelines
- Admission to hospital for acute exacerbation of COPD (AECOPD)
- Severe respiratory impairment defined by long-term oxygen therapy criteria: PaO2 < 7.3kPa or <8kPa with polycythemia, pulmonary hypertension, or right heart failure on room air, either previously or after clinical stabilization during hospitalization
- Affiliated with or beneficiary of social security coverage
- Able to read, understand information, and provide signed consent
- Women of childbearing potential must use effective contraception for at least 1 month and have a negative blood pregnancy test at screening
- Menopausal women must have confirmed diagnosis of menopause (amenorrhea for at least 12 months not medically induced)
You will not qualify if you...
- Age under 18 or over 85 years
- Current treatment with chronic non-invasive ventilation (NIV)
- Diagnosed obstructive sleep apnea (OSA) treated with CPAP, or screening indicating moderate to severe OSA (AHI > 30/h)
- Body Mass Index (BMI) over 35 kg/m2
- Hospital admission due to acute COVID-19 infection
- Hypercapnic respiratory failure requiring NIV (PaCO2 > 7 kPa) in stable condition within 6 months or persistent after discharge
- Pregnancy or ongoing lactation
- Significant psychiatric disorder or dementia affecting study adherence
- Tobacco use less than 10 pack-years
- Expected survival less than 12 months due to causes other than COPD
- Refusal of high-flow oxygen therapy
- Legal imprisonment or under judicial protection
- Participation in another research protocol affecting study outcomes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UHRouen
Rouen, France
Actively Recruiting
Research Team
A
Antoine CUVELIER, Pr
CONTACT
A
Armelle GUIDOTTI
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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