Actively Recruiting

Phase 3
Age: 50Years +
All Genders
NCT05904028

Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD

Led by Jaeb Center for Health Research · Updated on 2026-01-29

600

Participants Needed

64

Research Sites

194 weeks

Total Duration

On this page

Sponsors

J

Jaeb Center for Health Research

Lead Sponsor

N

National Institutes of Health (NIH)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Home optical coherence tomography- guided treatment versus treat and extend for the management of neovascular age-related macular degeneration.

CONDITIONS

Official Title

Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD

Who Can Participate

Age: 50Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 50 years or older
  • Ability to consent independently
  • Ability to complete at least one self-scanning session on the Home OCT device at the clinical site
  • Willingness to perform daily Home OCT monitoring tests for 2 years without interruptions longer than 14 days
  • Best corrected visual acuity of 24 ETDRS letters or better (about 20/320 Snellen) in the study eye
  • Untreated, active macular neovascularization lesion with fluid in the center 3 mm diameter area on OCT
  • At least one intermediate drusen (63 microns or larger) in either eye or late AMD (macular neovascularization or atrophy) in the other eye
Not Eligible

You will not qualify if you...

  • Previous treatment for macular neovascularization in the study eye with anti-VEGF or other AMD therapies
  • Prior intravitreal anti-VEGF or anti-Ang2 injections or macular laser treatment for any reason
  • Intravitreal corticosteroid treatment within the last 6 months
  • Any condition preventing participation or ability to complete daily Home OCT scans for 2 years (e.g., unstable medical status, dementia, Alzheimer's, uncontrollable tremors)
  • Macular neovascularization caused by other conditions such as ocular histoplasmosis, central serous choroidopathy, or pathologic myopia

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 64 locations

1

Kent W. Small, MD, AMC

Glendale, California, United States, 91203-1971

Actively Recruiting

2

Loma Linda University

Loma Linda, California, United States, 92354

Actively Recruiting

3

East Bay Retina Consultants, Inc.

Oakland, California, United States, 94609

Actively Recruiting

4

Kaiser Permanente - Oakland

Oakland, California, United States, 94611

Actively Recruiting

5

Southern California Desert Retina Consultants, Inc.

Palm Desert, California, United States, 92211

Actively Recruiting

6

UC Davis Health Eye Center

Sacramento, California, United States, 95817

Actively Recruiting

7

Macula Retina Vitreous Institute

Torrance, California, United States, 90503

Actively Recruiting

8

Bay Area Retina Associates A Medical Group

Walnut Creek, California, United States, 94598

Actively Recruiting

9

Retina Consultants

Manchester, Connecticut, United States, 06042

Actively Recruiting

10

National Ophthalmic Research Institute

Fort Myers, Florida, United States, 33912

Actively Recruiting

11

National Ophthalmic Research Institute

Fort Myers, Florida, United States, 33912

Actively Recruiting

12

University of Florida- Jacksonville

Jacksonville, Florida, United States, 32209

Actively Recruiting

13

Florida Retina Institute, James A. Staman, MD, PA- Jacksonville

Jacksonville, Florida, United States, 32216

Actively Recruiting

14

Argus Research Center, Inc

Naples, Florida, United States, 34105

Actively Recruiting

15

Southeast Eye Institute, P.A. dba Eye Associates of Pinellas

Pinellas Park, Florida, United States, 33782-4418

Actively Recruiting

16

Retina Associates of Sarasota

Sarasota, Florida, United States, 34233

Actively Recruiting

17

Sarasota Retina Institute

Sarasota, Florida, United States, 34239

Actively Recruiting

18

Retina Associates of Florida, LLC

Tampa, Florida, United States, 33609

Actively Recruiting

19

Southeast Retina Center, P.C.

Augusta, Georgia, United States, 30909

Actively Recruiting

20

Thomas Eye Group

Sandy Springs, Georgia, United States, 30328

Actively Recruiting

21

Northwestern Memorial Group

Chicago, Illinois, United States, 60611

Actively Recruiting

22

Rush University Medical Center

Chicago, Illinois, United States, 60612

Actively Recruiting

23

UIC - Dept of Ophthalmology & Visual Sciences

Chicago, Illinois, United States, 60612

Actively Recruiting

24

The Trustees of Indiana University

Indianapolis, Indiana, United States, 46202

Actively Recruiting

25

Midwest Eye Institute

Indianapolis, Indiana, United States, 46290

Actively Recruiting

26

Wolfe Clinic, P.C.- West Des Moines

West Des Moines, Iowa, United States, 50266

Actively Recruiting

27

Mid-America Retina Consultants, P.A.

Overland Park, Kansas, United States, 66211

Actively Recruiting

28

University of Kentucky Advanced Eye Care

Lexington, Kentucky, United States, 40508

Actively Recruiting

29

Elman Retina Group, BA

Baltimore, Maryland, United States, 21237

Actively Recruiting

30

Johns Hopkins University

Baltimore, Maryland, United States, 21287

Actively Recruiting

31

Valley Eye Physicians and Surgeons

Ayer, Massachusetts, United States, 01432

Actively Recruiting

32

Joslin Diabetes Center

Boston, Massachusetts, United States, 02215

Actively Recruiting

33

Henry Ford Health System

Detroit, Michigan, United States, 48202

Actively Recruiting

34

Retina Associates of Michigan

Grand Blanc, Michigan, United States, 48439

Actively Recruiting

35

Associated Retinal Consultants, P.C.

Royal Oak, Michigan, United States, 48073

Actively Recruiting

36

Associated Retinal Consultants

Traverse City, Michigan, United States, 49686

Actively Recruiting

37

The Retina Institute

St Louis, Missouri, United States, 63128

Actively Recruiting

38

Associated Retinal Surgeons d/b/a Mid Atlantic Retina

Cherry Hill, New Jersey, United States, 08034

Actively Recruiting

39

New York University Langone Health

New York, New York, United States, 10017

Actively Recruiting

40

Macula Care

New York, New York, United States, 10021

Actively Recruiting

41

Vitreous Retina Macula Consultants of NY - VRMNY

New York, New York, United States, 10022

Actively Recruiting

42

Retina Associates of Western NY, P.C.

Rochester, New York, United States, 14620

Actively Recruiting

43

The Cleveland Clinic Foundation DBA Cleveland Clinic Lerner College of Medicine

Cleveland, Ohio, United States, 44120

Actively Recruiting

44

Retina Vitreous Center

Edmond, Oklahoma, United States, 73013

Actively Recruiting

45

Verum Research LLC

Eugene, Oregon, United States, 97401

Actively Recruiting

46

Oregon Health & Science University

Portland, Oregon, United States, 97239

Actively Recruiting

47

Cascade Medical Research Institute, LLC

Springfield, Oregon, United States, 97477

Actively Recruiting

48

Retina Vitreous Consultants

Monroeville, Pennsylvania, United States, 15146

Actively Recruiting

49

The Trustees of the University of Pennsylvania

Philadelphia, Pennsylvania, United States, 19104

Actively Recruiting

50

Hilton Head Retina Institute

Hilton Head Island, South Carolina, United States, 29926

Actively Recruiting

51

Ophthalmology Ltd.

Sioux Falls, South Dakota, United States, 57108

Actively Recruiting

52

Southeastern Retina Associates, P.C.

Knoxville, Tennessee, United States, 37922

Actively Recruiting

53

Austin Research Center for Retina

Austin, Texas, United States, 78705

Actively Recruiting

54

Retina Consultants of Texas, PA

Bellaire, Texas, United States, 77401

Actively Recruiting

55

UT Southwestern Medical Center

Dallas, Texas, United States, 75390

Actively Recruiting

56

Southwest Retina Consultants

El Paso, Texas, United States, 79902

Actively Recruiting

57

Baylor College of Medicine, Baylor Eye Physicians and Surgeons

Houston, Texas, United States, 77030-4101

Actively Recruiting

58

Texas Retina Associates

Lubbock, Texas, United States, 79424

Actively Recruiting

59

Retina Associates of South Texas

San Antonio, Texas, United States, 78240

Actively Recruiting

60

Retinal Consultants of Texas

San Antonio, Texas, United States, 78240

Actively Recruiting

61

The Board of Regents of the University of Wisconsin System

Madison, Wisconsin, United States, 53705

Actively Recruiting

62

Eye Clinic of Wisconsin

Wausau, Wisconsin, United States, 54403

Actively Recruiting

63

Chow Berger Koushan Medicine Professional Corporation o/a Toronto Retina Institute

North YORK, Ontario, Canada, M3C0G9

Actively Recruiting

64

University Health Network

Toronto, Ontario, Canada, M5T 2S8

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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