Actively Recruiting
Home Rehabilitation Improves Cardiac Effort in Pulmonary Arterial Hypertension
Led by University of Rochester · Updated on 2025-09-10
55
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Rochester
Lead Sponsor
U
United Therapeutics
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating whether a home rehabilitation program can reduce cardiac effort and improve quality of life for patients diagnosed with Pulmonary Arterial Hypertension (PAH). The study aims to measure how much the heart works during a 6-minute walk test compared to the walking distance. The findings could help improve the management of PAH patients. Participants are randomly assigned to one of two groups. The experimental group receives daily exercise instructions with heart rate guidance through SMS texts or email. The control group receives daily messages without exercise tasks, such as general greetings, to maintain blinding and limit bias. The study duration for the main intervention and monitoring is 12 weeks. During the study, participants will be assessed for changes in cardiac effort and walking distance at the beginning and after three months. Researchers will monitor adherence through message delivery and compliance with home 6-minute walk tests. The study also includes clinical evaluations to ensure safety, with no planned medication changes during the trial unless necessary. Participant involvement lasts about three months with close monitoring throughout.
CONDITIONS
Brief Title
Home Rehabilitation Improves Cardiac Effort in Pulmonary Arterial Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Follows care at University of Rochester Medical Center Pulmonary Hypertension Clinic
- Adults aged 18 years or older
- Diagnosis of pulmonary arterial hypertension confirmed by right heart catheterization
- On stable vasodilator medication for at least 30 days with no planned dose changes during the study
- Access to a smartphone or email to receive daily messages
- Clinically stable as determined by the investigator
- Approved as safe to participate by the treating investigator before enrollment
You will not qualify if you...
- Pregnancy
- Pulmonary hypertension Groups 2-5
- Resting heart rate over 120 beats per minute during screening
- Inability to walk
- WHO Functional Class IV
- No access to email or text messaging
- Unable to follow daily instructions, including performing two home 6-minute walk tests during initial monitoring
- Currently participating in a self-reported rehabilitation or exercise program
- Using oxygen therapy over 6 L/min at rest
- Exclusion at Principal Investigator's discretion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 3 months
Participants receive daily behavioral interventions through messages with exercise guidance or standard messages without activity tasks.
Daily message delivery
Trial Site Locations
Total: 1 location
1
University of Rochester Medical Center
Rochester, New York, United States, 14642
Actively Recruiting
Research Team
D
Daniel Lachant, DO
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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