Actively Recruiting
HomeLink2: Reducing Posthospitalization Mortality Through Structured Home Care and Nutritional Support
Led by Johns Hopkins University · Updated on 2025-08-05
780
Participants Needed
1
Research Sites
188 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
People living with HIV (PLWH) are at high risk of poor health outcomes after being discharged from the hospital. This study is designed to test whether providing structured care at home-either with or without nutritional support-can help reduce the risk of death within six months of discharge and improve long-term health outcomes. The investigators are conducting a randomized clinical trial to evaluate the effectiveness of home-based care on post-hospital recovery. Participants are randomly assigned to one of three groups: (1) standard post-discharge care, (2) home-based care that includes medical assessments, support for taking HIV medications (adherence support), and psychosocial counseling, or (3) the same home-based care plus food parcels to support nutrition. This is a three-arm, individually randomized clinical trial and a type-1 hybrid implementation-effectiveness study, which means the investigators are not only testing whether the interventions improve health outcomes, but also examining how the interventions are delivered and whether the interventions are practical and acceptable in real-world settings. The trial begins with a pilot phase to test the investigators enrollment procedures and improve baseline data collection. In addition to measuring whether the interventions reduce the risk of death, the study will assess how many people receive the intervention, whether it is acceptable to patients and families, and how consistently it is delivered. The investigators are also evaluating the economic impact of illness, hospitalization, and death on households, and analyzing the cost and resource needs of delivering home-based care, with or without food support. The investigators goal is to provide evidence that can improve care for people living with HIV after hospital discharge. If effective, this approach may be applied more broadly to improve outcomes for other high-risk patients in similar settings. Findings from the study will be used to inform health policy and clinical practice, particularly in areas with limited resources and high HIV burden.
CONDITIONS
Official Title
HomeLink2: Reducing Posthospitalization Mortality Through Structured Home Care and Nutritional Support
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Documented HIV infection confirmed by clinical records or treatment documentation
- Age 18 years or older as shown in hospital or government records
- Residence within the Matlosana sub-district by self-report
- Admission to an adult internal medicine ward at Tshepong Hospital
- Hospital stay of at least 2 nights before joining the study
- Willingness to participate in follow-up including home visits
- Ability to provide informed consent or have a next of kin provide consent if unable
You will not qualify if you...
- Admission to non-medical wards such as surgical or psychiatric, elective admissions, or transfers to other hospitals
- Participant or next of kin unable to provide written informed consent in study languages or languages spoken by the study team
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tshepong Hospital
Klerksdorp, North West, South Africa
Actively Recruiting
Research Team
T
Tumelo Moloantoa
CONTACT
N
Neil Martinson
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here