Actively Recruiting
Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
Led by Shady Grove Fertility Reproductive Science Center · Updated on 2026-03-02
394
Participants Needed
3
Research Sites
70 weeks
Total Duration
On this page
Sponsors
S
Shady Grove Fertility Reproductive Science Center
Lead Sponsor
E
EMD Serono
Collaborating Sponsor
AI-Summary
What this Trial Is About
HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or immediate start (without a pause).
CONDITIONS
Official Title
Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ovary-bearing individuals 18 to 40 years of age
- Body mass index (BMI) less than 40 kg/m2
- Non-smoker for at least 3 months before enrollment
You will not qualify if you...
- Body mass index (BMI) 40 kg/m2 or higher
- Current smoker
- Any contraindications to ovarian stimulation or outpatient egg retrieval under anesthesia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Yale Fertility Center
Orange, Connecticut, United States, 06477
Actively Recruiting
2
Shady Grove Fertility Rockville
Rockville, Maryland, United States, 20850
Actively Recruiting
3
Reproductive Medicine Associates of New York
New York, New York, United States, 10022
Not Yet Recruiting
Research Team
T
Tasha Newsome, Clinical Research Supervisor
CONTACT
S
Seth J Barishansky, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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