Actively Recruiting
Hormone Therapy and Angiotensin-Dependent Arterial and Renal Vasoconstriction in Humans
Led by University of Calgary · Updated on 2025-03-27
200
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
1. to investigate the association between route of administration of exogenous estrogen (transdermal vs. oral) and cardiorenal risk in cisgender (gender identity aligning with sex at birth) and transgender (gender identity not aligning with sex at birth) women. 2. to investigate the association between exogenous testosterone exposure and cardiorenal risk in cisgender (gender identity aligning with sex at birth) and transgender (gender identity not aligning with sex at birth) men.
CONDITIONS
Official Title
Hormone Therapy and Angiotensin-Dependent Arterial and Renal Vasoconstriction in Humans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 90 years
- Taking hormones orally or non-orally (either estrogen, progesterone or testosterone)
You will not qualify if you...
- Cardiovascular disease including symptoms or history of myocardial ischemia, arrhythmias, valve abnormalities, or abnormal ECG at screening
- Cerebrovascular disease such as transient ischemic attacks or stroke
- History of hypertension (blood pressure greater than 140/90 or use of blood pressure medications)
- Estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2
- Diabetes mellitus defined by history, use of diabetes medications, or fasting glucose over 7 mmol/L
- Current smoker
- Previous history of preeclampsia
- Use of anabolic steroids, corticosteroids, or non-steroidal anti-inflammatory drugs, or as determined by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Calgary
Calgary, Alberta, Canada, T2N 4Z6
Actively Recruiting
Research Team
D
Darlene Y Sola, BScN
CONTACT
V
Victoria Riehl-Tonn, BN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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