Actively Recruiting
In Hospital 24 Hour Observation of Syncope Patients
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2026-02-24
640
Participants Needed
1
Research Sites
141 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Syncope is very common and has a broad differential diagnosis. Guidelines on syncope recommend to apply guideline based syncope algorithm (SA) to identify low- / intermediate risk syncope patients and recommend to discharge these patients. The time window when to discharge these patients is not defined in the guidelines. In current medical practice low- / intermediate risk syncope patients are either immediately discharged or discharged after 24-hour observation with telemetry (TM). There seems to be an equipoise for both treatment strategies in current medical practice for these low risk syncope patients. A randomized controlled trial to compare discharge after 24 hour observation including TM with immediate discharge has never been done on the Cardiac Emergency Room (CER).
CONDITIONS
Official Title
In Hospital 24 Hour Observation of Syncope Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
All patients that are assessed as low- and intermediate risk syncope, are eligible for inclusion in this trial.
The initial syncope evaluation includes:
- Complete and thorough history taking of the syncope event and past medical history
- Physical examination including supine and standing BP measurement and
- 12 lead ECG.
You will not qualify if you...
A potential patient who meets any of the following criteria will be excluded from participation in this study:
- Those aged <18 years
- Those in whom syncope / transient loss of consciousness co-exist with trauma or other serious condition identified in the CER (massive bleeding, pulmonary embolus) or any high-risk features upon assessment with guideline based SA
- Those with any other conditions then syncope / transient loss of consciousness for which admission is required (including social indication for admission, etc.)
- Contraindication for early discharge as the discretion of the responsible physician
- Those with a learning disability
- Those presenting with pre-syncope
- Those who are unwilling to provide informed consent (those will be asked to be enrolled for the SYNCOPE R.I.S.C-registry)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Amsterdam UMC
Amsterdam, Netherlands, 1105 AZ
Actively Recruiting
Research Team
F
Frederik de Lange, MD PhD
CONTACT
E
Elise Hulsman, RN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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