Observational Study of Hospitalized Adults With COVID-19 Across 12 Clinics in 11 Countries

What this Trial Is About

This research focuses on hospitalized adult patients diagnosed with COVID-19, aiming to understand how different SARS-CoV-2 variants and vaccination schedules affect the clinical outcomes of these patients. It is an observational multicenter study conducted across 12 clinics in 11 countries on 4 continents. The study also explores the impact of viral variants and vaccines on disease severity and treatment responses using biostatistical methods and artificial intelligence. Participants receive the standard care provided at their hospital while data and biological samples, such as blood and viral isolates, are collected for detailed analysis. The study includes both retrospective and prospective data collection from patients who tested positive for SARS-CoV-2 by PCR within 14 days before admission through hospital discharge. This observational study does not involve experimental treatments but monitors patients receiving usual care. Throughout the study, researchers collect clinical data on symptoms, interventions, and outcomes like mortality, ICU admissions, and mechanical ventilation use. They also track therapies such as renal replacement and blood transfusions. Data from biological samples support analysis of immune responses and viral characteristics. Participation involves data collection during hospitalization and follow-up over an average of four years to monitor severity and clinical outcomes related to COVID-19 and its variants.

Hospitalised COVID-19 Patients Cohort Study in the EuCARE Project