Actively Recruiting
How Metabolism Affects Weight Loss and Gain
Led by University Hospital Schleswig-Holstein · Updated on 2025-03-12
20
Participants Needed
1
Research Sites
45 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study examines why some individuals with obesity have difficulty losing weight, whereas some lean individuals struggle to gain weight. The investigators will measure how the human body uses energy during a fasting period and after consumption of a specially designed, low-protein meal. By comparing these responses, the investigators aim to identify different "metabolic phenotypes" that affect weight control. Findings from this research may lead to more personalized treatments for managing weight. Participation in this study involves simple tests and basic body measurements.
CONDITIONS
Official Title
How Metabolism Affects Weight Loss and Gain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- BMI 18.5-22.0 kg/m�b2 with difficulty gaining weight (lean group)
- BMI over 30 kg/m�b2 with difficulty losing weight (obese group)
- Healthy based on medical history, physical exam, and lab tests
- Stable weight with less than 5% change over the past 6 months
You will not qualify if you...
- Prediabetes or diabetes mellitus
- Conditions affecting appetite or energy use such as Cushing's syndrome or uncontrolled thyroid problems
- Gastrointestinal disorders affecting nutrient absorption like inflammatory bowel disease or ulcers
- Psychiatric conditions affecting eating such as active depression, anorexia nervosa, bulimia nervosa, or borderline personality disorder
- Recent acute or unstable cardiovascular disease needing hospitalization in last 6 months
- Cancer treated within the past 5 years
- Chronic kidney disease stage IV or higher
- Active infectious diseases such as HIV or hepatitis
- Current or recent nicotine use within one month prior to screening
- Use of illicit drugs like amphetamines, cocaine, heroin, or marijuana
- Regular high-intensity exercise of 1 hour or more per day
- Non-MRI-compatible metal implants like artificial joints or metal plates
- Pregnancy or breastfeeding
- Use of weight-loss medications
- Clinically significant claustrophobia
- Any other condition that might interfere with the study or participant safety as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Schleswig-Holstein
Kiel, Schleswig-Holstein, Germany, 24105
Actively Recruiting
Research Team
T
Tim Hollstein, PD Dr. med.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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