Actively Recruiting
HOXB7 and Linked Tissue and Blood Biomarkers in the Lungs of Patients With Pulmonary Fibrosis
Led by University of Modena and Reggio Emilia · Updated on 2026-02-04
80
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This pilot, multicenter, interventional study investigates the expression of HOXB7 and its associated molecular pathway in lung tissue and blood-derived exosomes from patients with pulmonary fibrosis (PF), including idiopathic pulmonary fibrosis (IPF). Using RNA sequencing (RNA-Seq) and proteomic analysis via mass spectrometry (MS), the study aims to identify tissue and circulating biomarkers associated with fibrosis progression. The study compares different biopsy techniques (surgical vs. transbronchial cryobiopsy) and also includes a control group of patients undergoing lung resection for non-fibrotic conditions.
CONDITIONS
Official Title
HOXB7 and Linked Tissue and Blood Biomarkers in the Lungs of Patients With Pulmonary Fibrosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 with clinical suspicion of pulmonary fibrosis
- Availability of fresh lung tissue from biopsy or lung explant
- Signed informed consent for research use of biological material and data
You will not qualify if you...
- Refusal to sign informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Azienda Ospedaliero Universitaria Policlinico di Modena
Modena, Italy
Actively Recruiting
Research Team
R
Roberto Tonelli
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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