Holmium:YAG Laser With MOSES Technology vs Thulium Fiber Laser in Supine Mini-percutaneous Nephrolithotomy With Vacuum-assisted Renal Access Sheath: A Prospective, Randomized Clinical Trial

What this Trial Is About

Researchers are studying the treatment of kidney stones larger than 2cm using a procedure called mini percutaneous nephrolithotripsy (miniPCNL). This procedure commonly uses laser energy to break stones, and the study compares two FDA-approved laser platforms: Holmium:YAG (HoYAG) laser with MOSES technology and the thulium fiber laser (TFL). The study aims to evaluate which laser platform provides better outcomes when combined with a new vacuum-assisted renal access sheath called ClearPetra™, which allows suction during stone breaking. Participants will be randomly assigned to one of two groups. One group will have miniPCNL using the ClearPetra™ sheath with the HoYAG laser, while the other group will use the same sheath with the TFL laser. Both groups will undergo the miniPCNL procedure according to standard care practices. The study specifically investigates differences in stone fragmentation efficiency and surgical outcomes between these two laser technologies. During the study, participants will undergo assessments including measurement of stone lithotripsy time, total operative time, laser energy used, and laser time during the procedure. Stone-free status will also be checked 90 days after surgery. The study is conducted by the University of Kansas Medical Center and will follow participants from the start of the procedure through follow-up visits to monitor outcomes and safety throughout the trial period ending in 2027.

HoYAG vs TFL in miniPCNL With ClearPetra