Actively Recruiting
HPI for Prevention of Hypotension During Cardiac Surgery
Led by Mackay Memorial Hospital · Updated on 2025-05-08
110
Participants Needed
1
Research Sites
197 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Hypotension prediction index (HPI) was applied in various types of non-cardiac surgery with convincing benefits of preventing hypotensive events and clinical sequelae. Although HPI was validated in cardiac surgery, its clinical benefits are not proven yet. We aim to evaluate its effects on intraoperative hypotension and postoperative adverse events in cardiac surgery. In this randomized, single-blind trial, we will enroll adults scheduled for elective primary cardiac surgery under general anesthesia. Participants will be randomly assigned to intraoperative HPI-guided or non-HPI-guided hemodynamic management. The primary endpoint is the time-weighted average intraoperative hypotension below a mean arterial pressure threshold of 65 mmHg. The secondary endpoints are postoperative complications.
CONDITIONS
Official Title
HPI for Prevention of Hypotension During Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult
- Scheduled for elective, primary, isolated coronary arterial bypass surgery (CABG) or isolated valve surgery
- Able to provide informed consent
You will not qualify if you...
- Have arrhythmia such as atrial fibrillation or atrial flutter
- Have intracardiac shunts
- Use preoperative inotropic medications
- Use preoperative supportive devices like intra-aortic balloon pump, extracorporeal membrane oxygenation, or ventricular assist devices
- Undergoing urgent or emergency surgery
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mackay memorial hospital
Taipei, Taiwan, 104
Actively Recruiting
Research Team
Y
Ying-Chun Lin, Master
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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