Actively Recruiting
HRD Tests for Ovarian cancER
Led by Centre Francois Baclesse · Updated on 2025-09-17
88
Participants Needed
4
Research Sites
380 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study concerns patients with Invasive epithelial ovarian cancer, primary Fallopian tube carcinoma, ovarian-type peritoneal carcinoma, and with an indication of a first-line platinum-based chemotherapy. To determine HRD status, 2 separate tests will be performed in the study: 1. Giscar assay : developed by the sponsor 2. myChoice assay If one or two tests identifies a HRD status : a PARP inhibitor treatment may be initiated according to current recommendations
CONDITIONS
Official Title
HRD Tests for Ovarian cancER
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient aged 18-year or more
- Histologically documented high grade serous epithelial ovarian cancer, fallopian tube or peritoneum cancer
- Newly diagnosed advanced (International Federation of Gynecology and Obstetrics [FIGO] stage III or IV) ovarian carcinoma, candidate to a first line platinum-based chemotherapy
- Tumor tissue must be available for HRD analyses (FFPE tissue block)
- Tumor tissue collected if possible during the initial surgery or the initial biopsy (before chemotherapy)
- Tumor tissue with sufficient tumour surface area (> 25 mm²), with a final cellularity of at least 20%
- Patient affiliated to an appropriate social security system
- Patient signed consent form before any trial related activities
You will not qualify if you...
- Recurrent high grade serous epithelial ovarian cancer, fallopian tube or peritoneum cancer
- Non epithelial or borderline ovarian cancer
- Other tumor, for which the treatment may interfere with the ovarian cancer treatment and/or that may have a major impact on prognosis
- Exclusive palliative setting
- Patient deprived of liberty or placed under the authority of a tutor
AI-Screening
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Trial Site Locations
Total: 4 locations
1
Chu Amiens
Amiens, France
Not Yet Recruiting
2
Centre Francois Baclesse
Caen, France
Actively Recruiting
3
Centre Oscar Lambret
Lille, France
Actively Recruiting
4
Centre Henri Becquerel
Rouen, France
Actively Recruiting
Research Team
R
Raphaël LEMAN, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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