Actively Recruiting
In-Human CXCR4 Imaging of Hematologic and Solid Tumors Using [68Ga]-Pentixafor-PET
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-02-05
30
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine the uptake of the imaging agent \[68Ga\]-pentixafor with PET/CT scans in people with monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), and non-Hodgkin lymphoma (NHL), or you have histiocytic neoplasms (Langerhans cell histiocytosis (LCH), Erdheim-Chester disease (ECD) and/or Rosai-Dorfman disease (RDD).
CONDITIONS
Official Title
In-Human CXCR4 Imaging of Hematologic and Solid Tumors Using [68Ga]-Pentixafor-PET
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed treatment-nafve, therapy-refractory, or relapsed blood cancers
- Diagnosis of indolent B- or T-cell Non-Hodgkin lymphoma (including cutaneous lymphomas) or mantle cell lymphoma with measurable disease by Lugano criteria
- Diagnosis of histiocytic neoplasms including Langerhans cell histiocytosis, Erdheim-Chester disease, or Rosai-Dorfman disease
- Diagnosis of MGUS, smoldering multiple myeloma, or multiple myeloma according to IMWG definitions
- Diagnosis of solid tumors such as lung cancers, meningioma, or adrenocortical neoplasms including cortisol-producing adenomas or high suspicion for tumor (e.g., patients with Cushing's disease)
- Age 18 years or older
- Negative serum pregnancy test within 2 weeks prior to enrollment or negative urine pregnancy test on day of intervention for females of childbearing potential
- Patients treated at MSKCC
You will not qualify if you...
- Currently breast-feeding
- History of renal functional disorders, including chronic kidney disease with eGFR less than 30
- Unable or unwilling to tolerate the scanning procedure (e.g., due to claustrophobia)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
Research Team
A
Anton Nosov, MD
CONTACT
H
Heiko Schoder, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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