Actively Recruiting
Human iPSC for Repair of Vasodegenerative Vessels in Diabetic Retinopathy
Led by University of Alabama at Birmingham · Updated on 2026-01-22
20
Participants Needed
1
Research Sites
520 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study proposes to carefully examine the hypothesis that human inducible pluripotent stem cells (iPSCs) can be effectively employed as a future therapeutic option for individuals with diabetic retinopathy and macular ischemia. iPSCs will be generated from the peripheral blood cells of subjects with diabetes and age matched controls. The human iPSC cells will be used to generate mesoderm cells for injection into the vitreous cavity of diabetic rodents and primate eyes. The ability of mesoderm cells to generate endothelial cells and pericytes in areas of degenerated capillaries will be examined. The human iPSCs will also be used to generate hematopoietic CD34+CD45+ cells. The combination of CD34+CD45+ cells derived from iPSCs and iPSC derived mesoderm will be examined in combination for their potentially beneficial effect to enhance the vessel formation.
CONDITIONS
Official Title
Human iPSC for Repair of Vasodegenerative Vessels in Diabetic Retinopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Any man or woman between the ages of 21 to 98 years
- Must have a diagnosis of diabetes or be a healthy age-matched control
- Willing and able to cooperate with eye exam and skin punch biopsy procedures
You will not qualify if you...
- Evidence of ongoing acute or chronic infection such as HIV, Hepatitis B or C, or tuberculosis
- Ongoing malignancy
- History of cerebral vascular accident or cerebral vascular procedure
- Current pregnancy
- History of organ transplantation
- Presence of a graft
- Patients with anemia
- Presence of age-related macular degeneration (AMD), glaucoma, uveitis, known hereditary degenerations, or other significant ocular complications besides diabetic retinopathy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
Research Team
J
Jennifer Moorer
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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