Study of New Biomarkers and Antigen Patterns in Human Leishmaniasis Using Serum Samples

What this Trial Is About

Researchers are studying Leishmaniasis, a parasitic infection, to identify specific biomarkers that could improve blood tests for detecting the disease. The study aims to find biomarkers that do not cross-react with other infections such as Chagas, tuberculosis, leprosy, or malaria. It also examines the Antigen Recognition Patterns ARPs of Leishmania infection and whether these patterns apply to different strains from Italy, Sudan, and other regions. The study involves analyzing stored and newly collected blood and serum samples from patients with confirmed Leishmaniasis, uninfected individuals, and those with other infections. Researchers use a specialized diagnostic test called Western blot to examine different protein fractions from Leishmania strains. They identify specific immunogenic proteins through laboratory techniques including mass spectrometry. Participants contribute blood samples that are tested and analyzed for biomarkers and ARPs. The study reviews these patterns at baseline to understand cross-reactions with other diseases. Samples come from multiple groups, including Leishmaniasis patients, healthy controls, and individuals with other infections. The research is observational with no assigned treatments, and participation involves providing samples and medical data. The study is expected to continue until November 2026.

Human Leishmaniasis: Antigen Recognition Pattern and Study of New Potential Biomarkers