Actively Recruiting
Human Leukocyte Antigen (HLA) Mismatched Related Allogeneic Hematopoietic Stem Cell Transplantation
Led by He Huang · Updated on 2025-02-05
29
Participants Needed
1
Research Sites
273 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a single center, prospective, single arm exploratory clinical trial that includes patients with hematological malignancies who are indicated for allogeneic hematopoietic stem cell transplantation (allo HSCT) but lack suitable donors. This project plans to use human leukocyte antigen (HLA) mismatched donors. Ultimately, a HLA mismatched allo HSCT transplantation plan will be established to improve the disease prognosis of these patients and truly enter the era of "everyone has a donor".
CONDITIONS
Official Title
Human Leukocyte Antigen (HLA) Mismatched Related Allogeneic Hematopoietic Stem Cell Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 60 years with hematological malignancies needing hematopoietic stem cell transplantation and no available related HLA identical sibling donors
- No donor available with HLA high-resolution typing 9/10 or higher, or urgency prevents finding donors
- No suitable HLA matching haploidentical donor available
- Suitable donor with mismatched HLA typing is available
- Participants or their legal representatives must sign informed consent before the study begins
You will not qualify if you...
- Severe liver function impairment (alanine aminotransferase >2.5 times upper limit) or kidney impairment (creatinine >1.5 times upper limit)
- Cardiopulmonary dysfunction including NYHA class III/IV heart function, ejection fraction below 50%, or severe ventilation dysfunction
- Active infections
- ECOG score 2 or higher
- Active secondary tumors
- Severe central nervous system or mental illness preventing autonomous consent
- Other contraindications to allogeneic hematopoietic stem cell transplantation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, China, China, 310003
Actively Recruiting
Research Team
Y
Yanmin Zhao, MD., PhD
CONTACT
Y
Yishan Ye, MD., PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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