Actively Recruiting
Human Leukocyte Antigen (HLA) Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation
Led by He Huang · Updated on 2025-02-05
29
Participants Needed
1
Research Sites
273 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a single center, prospective, single arm exploratory clinical trial that includes patients with hematological malignancies who are indicated for allogeneic hematopoietic stem cell transplantation (allo HSCT) but lack suitable donors. This project plans to use highly mismatched unrelated HLA mismatched donors. Ultimately, an unrelated human leukocyte antigen (HLA) mismatched allo HSCT transplantation plan will be established to improve the disease prognosis of this group of patients and truly enter the era of "everyone has a donor" for allo HSCT.
CONDITIONS
Official Title
Human Leukocyte Antigen (HLA) Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 60 years with blood cancers needing hematopoietic stem cell transplantation
- No matched blood donors with HLA high-resolution typing ≥ 9/10
- Difficulty finding matched donors due to urgent medical condition
- No suitable haploidentical HLA matched donor available
- Suitable unrelated HLA mismatched donors available (HLA typing < 9/10)
- Participant or legal representative has signed informed consent before study start
You will not qualify if you...
- Severe liver dysfunction (alanine aminotransferase > 2.5 times upper limit of normal)
- Severe kidney dysfunction (blood creatinine > 1.5 times upper limit of normal)
- Cardiopulmonary dysfunction (NYHA III/IV heart function, ejection fraction < 50%, severe lung dysfunction)
- Active infections
- ECOG performance status ≥ 2 points
- Active secondary tumors
- Severe central nervous system or mental illness preventing informed consent
- Other contraindications to allogeneic hematopoietic stem cell transplantation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, China, 310003
Actively Recruiting
Research Team
Y
Yishan Ye, MD., PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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