Actively Recruiting
Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults
Led by Queen's University · Updated on 2025-09-22
12
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
Sponsors
Q
Queen's University
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest. The main questions it aims to answer are: How much do skeletal muscle volume, strength, and fatigue resistance decline during bedrest? How much does whole-body insulin sensitivity change during bedrest? How do mitochondrial function and protein synthesis change during bedrest? Participants will undergo the following tests before and after a free-living control period and before and after a 5 day period of strict horizontal bedrest: * Magnetic resonance imaging of the thigh muscles * Strength testing of the thigh muscles * Insulin sensitivity testing in response to a mixed meal * Exogenous glucose oxidation in response to a mixed meal * Muscle biopsies from the thigh muscles * Blood samples
CONDITIONS
Official Title
Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females 18-30 years old
- BMI between 18.5 and 28 kg/m2
- Weight stable within plus or minus 2 kg for the past 6 months
- Generally healthy as assessed by medical and physical activity questionnaires
- Recreationally active
You will not qualify if you...
- BMI below 18.5 or above 28 kg/m2
- Use of insulin to control blood glucose levels
- History of cardiovascular, respiratory, metabolic, neuromuscular, or bone-wasting diseases
- Use of medications that affect muscle protein turnover (e.g., androgen or anabolic hormone therapy, chemotherapy)
- History of thrombosis, platelet or coagulation disorders, antiplatelet therapy, or anticoagulant medication use
- Presence of unremoved or partially removed metals under the skin
- History of head or eye injury involving metal fragments
- Having implanted electrical devices like pacemakers or neurostimulators
- Having implanted metal objects from surgery such as artificial joints or aneurysm clips
- Being pregnant or possibly pregnant
- Wearing metal braces on teeth
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Queen's Univeristy
Kingston, Ontario, Canada, K7L 3N6
Actively Recruiting
Research Team
C
Chris McGlory, PhD.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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