Study of Human Umbilical Cord Mesenchymal Stem Cells with Bovine Type I Collagen for Healing Third-Degree Burn Wounds in Adults

What this Trial Is About

Researchers are evaluating the safety and tolerability of human umbilical cord mesenchymal stem cells combined with bovine type I collagen for treating third-degree burn wounds. This study is designed as a single-center, randomized, double-blind, placebo-controlled exploratory clinical trial involving adults aged 18 to 65 years with confirmed third-degree burns. The trial aims to assess wound healing and tissue repair over a period extending up to 12 months. Participants will be randomly assigned to one of three groups a combination therapy group receiving human umbilical cord mesenchymal stem cells with bovine type I collagen, a control group receiving bovine type I collagen alone, or a placebo group treated with sterile blank dressing or Vaseline gauze. Treatments are applied to the burn wounds, and the study will monitor the safety and tolerability of these interventions. Throughout the study, participants will be followed for wound healing progress, with primary outcomes including the area of re-epithelialization up to 6 months and complete burn wound healing up to 12 months. Researchers will perform assessments at regular intervals to monitor healing and safety. Participants are expected to cooperate and complete follow-up visits to support comprehensive evaluation of treatment effects and tolerability.

HUMSCs Combined With Col I to Third-Degree Burn Wound