Actively Recruiting
Hyaluronan-enriched Medium and Euploid Blastocyst Transfers
Led by ART Fertility Clinics LLC · Updated on 2025-03-12
783
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
It has been proposed that enriching transfer media with hyaluronan (EmbryoGlue medium) improves pregnancy outcomes compared with media containing lower concentrations of this molecule. However, none of previous studies included preimplantation genetic testing for aneuploidy (PGT-A) embryos. In order to investigate the impact of this hyaluronan-enriched on pregnancy outcomes, it is essential to evaluate its efficacy on euploid-only embryo transfers. The aim of the present study is to evaluate whether a short period of exposure of euploid blastocysts to EmbryoGlue prior to and during transfer positively impact on pregnancy outcomes of frozen embryo transfer (FET) cycles.
CONDITIONS
Official Title
Hyaluronan-enriched Medium and Euploid Blastocyst Transfers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All frozen embryo transfer (FET) cycles with euploid blastocysts biopsied and vitrified on Day 5 after PGT-A.
- Rank of randomization based on embryo quality.
- Only hormonal replacement therapy (HRT) cycle regimen.
- Women aged 18 years to 46 years.
- Having at least 1 chromosomally normal vitrified blastocyst(s) on Day 5 available for transfer.
- All sperm samples.
- BMI between 18 and 35.
You will not qualify if you...
- FET cycles with preimplantation genetic testing for monogenic disorders (PGT-M) and for structural rearrangements (PGT-SR).
- FET cycles with mosaic / aneuploid blastocysts.
- FET cycles with unknown outcome.
- FET cycles with Day 6 or Day 7 biopsied blastocysts.
- FET with patients' endometrium preparation with treatments other than HRT.
- FET where PGT-A was performed for gender selection.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
ART Fertility Clinics LLC
Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates, 60202
Actively Recruiting
Research Team
D
Daniela Nogueira
CONTACT
J
Jonalyn DV Edades, Nursing
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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