Actively Recruiting
Hyaluronic Acid in Endodontic Microsurgery
Led by University of Bern · Updated on 2026-03-30
46
Participants Needed
1
Research Sites
149 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized clinical trial (RCT) will evaluate the effectiveness of cross-linked hyaluronic acid as an adjunct to endodontic microsurgery in adult patients with apical periodontitis affecting maxillary or mandibular first molars. Participants previously treated with non-surgical endodontic therapy will be allocated to either endodontic microsurgery with cross-linked hyaluronic acid application (test group) or the same surgical procedure without adjunctive material (control group), with 12 months of follow-up. The study hypothesis is that cross-linked hyaluronic acid improves soft- and hard-tissue healing, reduces postoperative inflammation and pain, and supports more stable surgical outcomes. Primary outcomes include early soft tissue healing (Early Wound Healing Score, day 4) and postoperative pain (visual analogue scale). Secondary outcomes include periapical healing assessed by blinded evaluators on periapical radiographs (Molven criteria) at 3, 6, and 12 months, and on CBCT scans (PENN 3D criteria) at 6 and 12 months, as well as cortical plate healing (RAC/B index). This study aims to provide clinical evidence on the potential regenerative and anti-inflammatory benefits of cross-linked hyaluronic acid in endodontic microsurgery.
CONDITIONS
Official Title
Hyaluronic Acid in Endodontic Microsurgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent
- 18 years of age or older
- Apical periodontitis in maxillary or mandibular first molars at least 12 months after non-surgical endodontic treatment
- Full mouth plaque score and bleeding score less than or equal to 20%
- Periapical lesion less than or equal to 10 mm
- Four-wall bone defect morphology
You will not qualify if you...
- Smoking more than 10 cigarettes a day
- Allergy to hyaluronic acid
- Pregnancy or lactation
- Uncontrolled diabetes
- Untreated periodontal conditions
- Conditions associated with poor compliance or inability to maintain good oral hygiene
- Acute infections in the area intended for surgery
- Receiving chemotherapy or radiotherapy treatment
AI-Screening
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Trial Site Locations
Total: 1 location
1
Praktika 1
Moscow, Russia, 127006
Actively Recruiting
Research Team
A
Anton Sculean, Prof.
CONTACT
V
Vitaly Fuog, DMD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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