Actively Recruiting
Hyaluronic Acid Filler Migration
Led by Erevna Innovations Inc. · Updated on 2026-01-22
10
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Soft tissue filler injections continue to grow in popularity as a method of facial rejuvenation, including volume restoration and contour enhancement. Many different hyaluronic acid (HA)-based fillers are available on the market and differ in terms of their physical and chemical properties, which results in families of fillers (e.g., Non-Animal Stabilized Hyaluronic Acid - NASHA vs. Optimal Balance Technology - OBT) with different tissue integration patterns. It has been proposed that the properties of fillers significantly influences their tendency to migrate. More specifically, thick fillers may be less prone to migration compared to fluid fillers. However, a detailed knowledge of facial anatomy, safer injection techniques, and careful product selection based on filler qualities may be preventive measures for filler migration. The goal of this study is to describe the short and intermediate-term product distribution/integration patterns of NASHA and OBT-based fillers, and to evaluate the evidence (if any) of filler migration from the intended site of injection.
CONDITIONS
Official Title
Hyaluronic Acid Filler Migration
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female participants 18 years of age and older
- Established facial volume loss and/or contour deficits
- Agree not to receive any other facial procedures during the study
- Able and willing to attend all scheduled follow-up visits
- No facial fillers in the 18 months prior to the study
- Capable of providing informed consent
- Willing and able to follow study procedures
- In good health as judged by the investigator
- Female participants of childbearing potential agree to use effective birth control from baseline through 30 days after last dose or study end
You will not qualify if you...
- Currently pregnant or breastfeeding
- Hypersensitivity to Restylane, hyaluronic acid fillers, or amide local anesthetics
- Porphyria or other liver diseases
- Unable to comply with follow-up or abstain from facial injections during study
- Smoking more than 12 cigarettes per day
- History of severe or multiple allergies with anaphylaxis
- Facial tissue revitalization therapy within 6 months before treatment
- Previous facial surgery including liposuction
- Permanent implants in the treatment area
- Semi-permanent dermal fillers, synthetic implants, or autologous fat transplantation in last 18 months
- Disease or lesions near treatment area, including infections
- Uncontrolled systemic diseases
- Medical conditions increasing risks with HA exposure or interfering with study
- Facial skin conditions increasing infection risk
- Scars, deformities, piercings, or tattoos in treatment areas
- Facial cancer or precancer
- History of radiation therapy to treatment area
- Bleeding disorders or recent use of blood-thinning medications
- Active immune disorders or use of immunosuppressants
- Tendencies for abnormal scarring or healing disorders
- Hypersensitivity to lidocaine or related anesthetics
- Recent dental block or lidocaine topical use
- Epilepsy, cardiac conduction issues, severe liver or kidney problems
- Current infections
- Planned dental procedures 2 weeks before or after treatment
- Planned COVID-19 vaccinations 2 weeks before or after treatment
- History of cystic acne in chin region
- Considering pregnancy or egg donation during or shortly after study
- Anticipated surgery or hospitalization during study
- Other treatments that might interfere or increase risk
- Contraindications to MRI including pacemakers, metal implants, claustrophobia, pregnancy, or sensitivity to loud noises
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Erevna Innovations Inc.
Westmount, Quebec, Canada, H3Z 1C3
Actively Recruiting
Research Team
L
Laura Raco
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here