Actively Recruiting
Hyaluronic Acid and Octenidine Gel as an Adjunct to Non-surgical Periodontal Treatment
Led by Queen Mary University of London · Updated on 2026-02-05
26
Participants Needed
2
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This parallel-group, pilot study will test the hypothesis that the adjunctive use of a thermosensitive gel containing Hyaluronic Acid (HA) and Octenidine to non-surgical periodontal treatment (NSPT) will be able to modulate the early wound healing events. This will be assessed through the expression of specific gingival crevicular fluid markers, as well as by changes in gingival blood flow (assessed by laser speckle contrast imaging), bacterial load, soft tissues contour, clinical parameters and patient-reported outcomes. The study will involve up to 26 patients and will take place at the Centre for Oral Clinical Research (COCR), at the Institute of Dentistry, Faculty of Medicine and Dentistry, Queen Mary University of London under The Royal London Dental Hospital, Barts Health NHS Trust. Patients will be randomised to receive either NSPT alone or NSPT+ HA and Octenidine gel, and will be followed up to 3 months after treatment. The study will consist of 7- 8 visits.
CONDITIONS
Official Title
Hyaluronic Acid and Octenidine Gel as an Adjunct to Non-surgical Periodontal Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 and above
- Patients with Full Mouth Plaque Score (FMPS) of 20% or less within 6 weeks before enrollment, or showing at least 50% plaque score reduction from initial screening
- Periodontitis stage III or IV (grades A to C) with at least one site per quadrant having probing pocket depth of 5 mm or more, bleeding on probing, and attachment loss of 5 mm or more
- Willing to sign informed consent and follow study procedures
You will not qualify if you...
- Known allergy or hypersensitivity to any component of the study product
- Pregnancy or lactation
- Current or recent smoking within past 5 years, including e-cigarettes or vaping
- Medical history of diabetes, serious medical or psychiatric conditions, or infectious diseases increasing study risks
- Need for prophylactic antibiotics before dental procedures or antibiotic use within 3 months before baseline
- Chronic treatment with anti-inflammatory drugs, anticoagulants, immunosuppressants, or other medications affecting wound healing
- History of alcohol or drug abuse
- Professional subgingival plaque removal (beyond limited debridement) or periodontal surgery within past 12 months
- Severe medical or psychiatric conditions or limited mental capacity/language skills preventing informed consent or following instructions
- Any other condition judged by the investigator to make participation inappropriate
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Centre for Oral Clinical Research (COCR)
London, United Kingdom, E1 2AD
Actively Recruiting
2
The Royal London Dental Hospital, Barts Health NHS Trust
London, United Kingdom, E1 2AD
Actively Recruiting
Research Team
M
Miljana Bacevic, DDS, PhD
CONTACT
J
Jeniffer Perussolo, DDS, MS, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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