Using Bovine Bone Graft with Hyaluronic Acid Gel for Tooth Socket Preservation and Full Digital Workflow Dental Implant Rehabilitation

What this Trial Is About

Researchers are evaluating the use of a bovine-derived bone graft combined with a polynucleotides-rich hyaluronic acid PNHA gel to preserve bone after tooth extraction and to test a fully-digital method for placing dental implants. This single-center, double-blind randomized controlled trial involves 40 patients needing a single tooth extraction, comparing spontaneous healing to the use of the bone graft and PNHA gel for alveolar ridge preservation. Participants will be randomly assigned to either a control group with no biomaterial placed in the extraction socket or to a treatment group receiving a bone graft mixed with PNHA gel and covered with a collagen matrix. Four months after extraction, an implant will be placed in the site and rehabilitated using a fully-digital workflow. The study includes 11 visits over at least 20 months, with follow-up continuing up to 12 months after implant loading. Patients will undergo two 3D x-rays to assess bone changes immediately after extraction and at 4 months, plus clinical evaluations of healing and questionnaires about quality of life and therapy perception. Wound fluid samples will be collected during early healing, and bone tissue samples will be taken at implant placement for detailed analysis. The main measure is the change in alveolar ridge width at 4 months, along with assessments of bone quality, protein expression, healing indexes, implant success, and patient satisfaction.

Hyaluronic Acid and Polynucleotides in Ridge Preservation