Actively Recruiting
Hyaluronic Acid and Polynucleotides for Supra-bony Defects
Led by Queen Mary University of London · Updated on 2025-06-08
24
Participants Needed
2
Research Sites
110 weeks
Total Duration
On this page
Sponsors
Q
Queen Mary University of London
Lead Sponsor
G
Geistlich Pharma AG
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this pilot study is to describe the early wound healing molecular events and the vascularization pattern associated with the treatment of supra-bony defects with access flap alone or in association with a combined formulation of hyaluronic acid and polydeoxyribonucleotides gel.
CONDITIONS
Official Title
Hyaluronic Acid and Polynucleotides for Supra-bony Defects
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Systemically healthy males and females 18 years or older
- Diagnosis of stage III or IV periodontitis
- Presence of supra-bony periodontal defects confirmed clinically and radiographically on 2 to 4 adjacent teeth with probing pocket depth greater than 5 mm after non-surgical periodontal therapy
- Intrabony component of defects must be 2 mm or less if present
- Completed non-surgical periodontal treatment within the previous 4 months
- Full-mouth bleeding score and full-mouth plaque score of 20% or less
You will not qualify if you...
- Teeth with degree III mobility
- Multi-rooted teeth with grade 2 or higher furcation involvement
- Heavy smokers who smoke 10 or more cigarettes per day
- Untreated caries, endodontic lesions, or abscesses on teeth involved in surgery
- Previous periodontal surgery in the study area
- Conditions requiring prophylactic antibiotics before dental procedures (e.g., mitral valve prolapse, artificial heart)
- Antibiotic or anticoagulant therapy in the month before baseline exam
- History of alcohol or drug abuse
- Uncontrolled diabetes, liver or kidney diseases, or other serious medical conditions affecting periodontal health
- Current use of medications affecting bone metabolism or blood clotting (e.g., anticoagulants, long-term corticosteroids, bisphosphonates, immunosuppressants)
- Pregnancy or lactation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Barts Health NHS Trust Dental Hospital
London, United Kingdom, E1 1BB
Actively Recruiting
2
Centre for Oral Clinical Research (COCR)
London, United Kingdom, E1 2AD
Actively Recruiting
Research Team
M
Miljana Bacevic
CONTACT
E
Elena Calciolari, DDS, MS, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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